Dissertation/Thesis
Exploring appropriate offset values for pencil beam and Monte Carlo dose optimization in lung stereotactic body radiotherapy encompassing the effects of respiration and tumor location
| Title: | Exploring appropriate offset values for pencil beam and Monte Carlo dose optimization in lung stereotactic body radiotherapy encompassing the effects of respiration and tumor location |
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| Contributors: | Evans, Grant (author), Shang, Charles (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Physics |
| Publisher Information: | Florida Atlantic University |
| Collection: | FAU Digital Collections (Florida Atlantic University Digital Library) |
| Subject Terms: | Drug development -- Computer simulation, Image guided radiation therapy, Lung cancer -- Treatment, Monte Carlo method, Proton beams, Transport theory |
| Description: | Evaluation of dose optimization using the Pencil Beam (PB) and Monte Carlo (MC) algorithms may allow physicists to apply dosimetric offsets to account for inaccuracies of the PB algorithm for lung cancer treatment with Stereotactic Body Radiotherapy (SBRT). 20 cases of Non-Small Cell Lung Cancer (NSCLC) were selected. Treatment plans were created with Brainlab iPlanDose® 4.1.2. The D97 of the Planning Target Volume (PTV) was normalized to 50 Gy on the Average Intensity Projection (AIP) using the fast PB and compared with MC. This exact plan with the same beam Monitor Units (MUs) was recalculated over each respiratory phase. The results show that the PB algorithm has a 2.3-2.4% less overestimation at the maximum exhalation phase than the maximum inhalation phase when compared to MC. Significantly smaller dose difference between PB and MC is also shown in plans for peripheral lesions (7.7 ± 0.7%) versus central lesions (12.7±0.8%)(p< 0.01). ; Includes bibliography. ; Thesis (M.S.)--Florida Atlantic University, 2014. ; FAU Electronic Theses and Dissertations Collection |
| Document Type: | Thesis |
| File Description: | 83 p.; application/pdf; Electronic Thesis or Dissertation |
| Language: | English |
| Relation: | FA00004105; http://purl.flvc.org/fau/fd/FA00004105; https://fau.digital.flvc.org/islandora/object/fau%3A13442/datastream/TN/view/%20Exploring%20appropriate%20offset%20values%20for%20pencil%20beam%20and%20Monte%20Carlo%20dose%20optimization%20in%20lung%20stereotactic%20body%20radiotherapy%20encompassing%20the%20effects%20of%20respiration%20and%20tumor%20location.jpg |
| Availability: | http://purl.flvc.org/fau/fd/FA00004105 https://fau.digital.flvc.org/islandora/object/fau%3A13442/datastream/TN/view/%20Exploring%20appropriate%20offset%20values%20for%20pencil%20beam%20and%20Monte%20Carlo%20dose%20optimization%20in%20lung%20stereotactic%20body%20radiotherapy%20encompassing%20the%20effects%20of%20respiration%20and%20tumor%20location.jpg |
| Rights: | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. ; http://rightsstatements.org/vocab/InC/1.0/ |
| Accession Number: | edsbas.8917C01D |
| Database: | BASE |
| Description not available. |