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Disparities in the Use of Programmed Death 1 Immune Checkpoint Inhibitors

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Τίτλος: Disparities in the Use of Programmed Death 1 Immune Checkpoint Inhibitors
Συγγραφείς: O'Connor, Jeremy M., Seidl-Rathkopf, Kathi, Torres, Aracelis Z., You, Paul, Carson, Kenneth R., Ross, Joseph S., Gross, Cary P.
Πηγή: The Oncologist ; volume 23, issue 11, page 1388-1390 ; ISSN 1083-7159 1549-490X
Στοιχεία εκδότη: Oxford University Press (OUP)
Έτος έκδοσης: 2018
Περιγραφή: Amid growing excitement for immune checkpoint inhibitors of programmed death protein 1 (anti-PD1 agents), little is known about whether race- or sex-based disparities exist in their use. In this observational study, we constructed a large and mostly community-based cohort of patients with advanced stage cancers, including melanoma, non-small cell lung cancer (NSCLC), and renal cell carcinoma, to compare the odds of receiving systemic treatment with or without anti-PD1 agents by race and by sex. In multivariable models that adjusted for age, stage, and number of prior anticancer therapies, we found no significant race-based disparities in anti-PD1 treatment. However, among patients with NSCLC, males had significantly higher odds of receiving anti-PD1 treatment compared with females (odds ratio 1.13, 95% confidence interval 1.02–1.24, p = .02). This finding suggests that as anti-PD1 agents enter the market to transform patient care, it will be critical to monitor for disparities in the use of these drugs.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
DOI: 10.1634/theoncologist.2017-0673
Διαθεσιμότητα: https://doi.org/10.1634/theoncologist.2017-0673
https://onlinelibrary.wiley.com/doi/pdf/10.1634/theoncologist.2017-0673
https://onlinelibrary.wiley.com/doi/full-xml/10.1634/theoncologist.2017-0673
https://academic.oup.com/oncolo/article-pdf/23/11/1388/41914749/oncolo_23_11_1388.pdf
Rights: https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
Αριθμός Καταχώρησης: edsbas.86DDE11A
Βάση Δεδομένων: BASE
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  – Url: https://doi.org/10.1634/theoncologist.2017-0673#
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  Data: <searchLink fieldCode="AR" term="%22O'Connor%2C+Jeremy+M%2E%22">O'Connor, Jeremy M.</searchLink><br /><searchLink fieldCode="AR" term="%22Seidl-Rathkopf%2C+Kathi%22">Seidl-Rathkopf, Kathi</searchLink><br /><searchLink fieldCode="AR" term="%22Torres%2C+Aracelis+Z%2E%22">Torres, Aracelis Z.</searchLink><br /><searchLink fieldCode="AR" term="%22You%2C+Paul%22">You, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Carson%2C+Kenneth+R%2E%22">Carson, Kenneth R.</searchLink><br /><searchLink fieldCode="AR" term="%22Ross%2C+Joseph+S%2E%22">Ross, Joseph S.</searchLink><br /><searchLink fieldCode="AR" term="%22Gross%2C+Cary+P%2E%22">Gross, Cary P.</searchLink>
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  Data: The Oncologist ; volume 23, issue 11, page 1388-1390 ; ISSN 1083-7159 1549-490X
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  Data: Amid growing excitement for immune checkpoint inhibitors of programmed death protein 1 (anti-PD1 agents), little is known about whether race- or sex-based disparities exist in their use. In this observational study, we constructed a large and mostly community-based cohort of patients with advanced stage cancers, including melanoma, non-small cell lung cancer (NSCLC), and renal cell carcinoma, to compare the odds of receiving systemic treatment with or without anti-PD1 agents by race and by sex. In multivariable models that adjusted for age, stage, and number of prior anticancer therapies, we found no significant race-based disparities in anti-PD1 treatment. However, among patients with NSCLC, males had significantly higher odds of receiving anti-PD1 treatment compared with females (odds ratio 1.13, 95% confidence interval 1.02–1.24, p = .02). This finding suggests that as anti-PD1 agents enter the market to transform patient care, it will be critical to monitor for disparities in the use of these drugs.
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