Academic Journal
Disparities in the Use of Programmed Death 1 Immune Checkpoint Inhibitors
| Τίτλος: | Disparities in the Use of Programmed Death 1 Immune Checkpoint Inhibitors |
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| Συγγραφείς: | O'Connor, Jeremy M., Seidl-Rathkopf, Kathi, Torres, Aracelis Z., You, Paul, Carson, Kenneth R., Ross, Joseph S., Gross, Cary P. |
| Πηγή: | The Oncologist ; volume 23, issue 11, page 1388-1390 ; ISSN 1083-7159 1549-490X |
| Στοιχεία εκδότη: | Oxford University Press (OUP) |
| Έτος έκδοσης: | 2018 |
| Περιγραφή: | Amid growing excitement for immune checkpoint inhibitors of programmed death protein 1 (anti-PD1 agents), little is known about whether race- or sex-based disparities exist in their use. In this observational study, we constructed a large and mostly community-based cohort of patients with advanced stage cancers, including melanoma, non-small cell lung cancer (NSCLC), and renal cell carcinoma, to compare the odds of receiving systemic treatment with or without anti-PD1 agents by race and by sex. In multivariable models that adjusted for age, stage, and number of prior anticancer therapies, we found no significant race-based disparities in anti-PD1 treatment. However, among patients with NSCLC, males had significantly higher odds of receiving anti-PD1 treatment compared with females (odds ratio 1.13, 95% confidence interval 1.02–1.24, p = .02). This finding suggests that as anti-PD1 agents enter the market to transform patient care, it will be critical to monitor for disparities in the use of these drugs. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| DOI: | 10.1634/theoncologist.2017-0673 |
| Διαθεσιμότητα: | https://doi.org/10.1634/theoncologist.2017-0673 https://onlinelibrary.wiley.com/doi/pdf/10.1634/theoncologist.2017-0673 https://onlinelibrary.wiley.com/doi/full-xml/10.1634/theoncologist.2017-0673 https://academic.oup.com/oncolo/article-pdf/23/11/1388/41914749/oncolo_23_11_1388.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| Αριθμός Καταχώρησης: | edsbas.86DDE11A |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1634/theoncologist.2017-0673 |
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