Academic Journal
Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects
| Τίτλος: | Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects |
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| Συγγραφείς: | Nunes, Caroline Brito, Rukins, Valentina, Cisse, Aminata H., White, Frédérique, McBride, Nancy, Kuang, Alan, Allard, Catherine, Ronkainen, Justiina, Hughes, Alice, Elliott, Amanda, Thorleifsson, Gudmar, Vaudel, Marc, Laisk, Triin, Gu, Yuqin, Lamri, Amel, Chen, Li, Tuhkanen, Johanna, Lahti, Jari, Calas, Lucinda, Muntaner, Manon, Karhunen, Ville, Choi, Jun Ho, Heiskala, Anni, Hatem, Gad, Fragoso-Bargas, Nicolás, Rifas-Shiman, Sheryl L., Paz-Lopez, Guillermo, Stinson, Sara E., Bhowmik, Bishwajit, Ahlqvist, Emma, Deleuze, Jean-Francois, Eriksson, Johan G., Park, S.K., Teo, Koon, Katri, Räikkönen, Stefansson, Kari, Molina‐Vega, María, Subbarao, Padmaja, Beaumont, Robin N, Johansson, Stefan, Tuomi, Tiinamaija, Hansen, T C Bog, Engelbrechtsen, Line, Morcillo, Sonsoles, Oken, Emily, Quigstad, Elisabeth, Birkeland, Kåre I, Vääräsmäki, Marja, Hattersley, Andrew T, Sebert, Sylvain, Hitman, G. A., Kwak, Soo Heon, Järvelin, Marjo-Riitta, Prasad, Rashmi B., Heude, Barbara, Meirhaeghe, Aline, Bouchard, Luigi, Jacques, Pierre‐Étienne, Laivuori, Hannele, Tan, Kok Hian, Anand, Sonia S., van Heel, David A., Liu, Siyang, Njølstad, Pål R., Steinthórsdóttir, Valgerður, Widen, Elisabeth, Keikkala, Elina, Scholtens, Denise M, Lowe, William L, Finer, Sarah, Morris, Andrew P., Mägi, Reedik, Zöllner, Julia, Borges, Maria Carolina, Lawlor, Debbie, Freathy, Rachel M., Evans, David M, Moen, Gunn-Helen |
| Συνεισφορές: | Department of Psychology, HUS Group, Clinicum, Department of General Practice and Primary Health Care, Department of Medicine, HUS Abdominal Center, Institute for Molecular Medicine Finland, Tiinamaija Tuomi Research Group, Centre of Excellence in Complex Disease Genetics, Helsinki Institute of Life Science HiLIFE, Endokrinologian yksikkö, Genomics of Neurological and Neuropsychiatric Disorders, Department of Medical and Clinical Genetics, HUS Physiology, Genetics and Preanalytics, Elisabeth Ingrid Maria Widen / Principal Investigator, Genomic Discoveries and Clinical Translation |
| Στοιχεία εκδότη: | Nature Publishing Group |
| Έτος έκδοσης: | 2026 |
| Συλλογή: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| Θεματικοί όροι: | Birth-weight, Genome-wide association, Glucose-tolerance, Insulin sensitivity, Plasma-glucose, Regression, Risk, Secretion, Variants, Women, General medicine, internal medicine and other clinical medicine |
| Περιγραφή: | Gestational diabetes mellitus (GDM) affects ~14% of pregnancies and increases maternal type 2 diabetes mellitus (T2DM) risk. The GenDiP Consortium presents trans-generational, multi-ancestry genome-wide association study meta-analyses of GDM and pregnancy glycemic traits in up to 38,305 GDM cases and 776,145 controls. We identify 37 GDM-associated loci (7 novel) and five novel loci for pregnancy glycemic traits, all operating through the maternal genome. We classify 12 GDM variants with stronger effects in GDM than T2DM into five biologically informed categories, revealing pleiotropy patterns, pregnancy-dependent effect modification, and diagnostic heterogeneity. While all these loci overlap with T2DM and/or non-pregnant glycaemic traits, four (G6PC2, CAST-PCSK1, HKDC1, FOXA2) lack genome-wide-significant T2DM associations; GCK shows distinct causal variants for GDM, and MTNR1B exhibits pregnancy-amplified effects. Our findings provide new genetic insights into GDM and highlight the need for larger, ancestrally diverse studies of GDM and glycaemic traits during pregnancy to understand potential pregnancy-specific effects. ; Peer reviewed |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISBN: | 978-0-01-782195-9 0-01-782195-9 |
| Relation: | G.H.M. discloses support for the research and publication of this work from the Australian Research Council (DE220101226) and the Research Council of Norway (325640). D.M.E. discloses support for the research of this work from the National Health and Medical Research Council (2017942). S.L. discloses support for the research of this work from the National Natural Science Foundation of China (32470642, 31900487), the Guangdong Natural Science Foundation (2022B1515120080) and the Shenzhen Science and Technology Program (20220818100717002). S.E.S. discloses support for the research of this work from the Novo Nordisk Foundation (NNF18CC0033668, NNF18CC0034900, NNF23SA0084103). S.K., J.C. disclose support for the research of this work from the National Human Genome Research Institute (U01HG011723). S.M. discloses support for the research of this work from the Programa Nicolas Monardes del Servicio Andaluz de Salud, Junta de Andalucia, Spain (RC-0008-2021). M.M.-V. discloses support for the research of this work from the Instituto de Salud Carlos III (JR20-00040). D.A.L., M.C.B. and N.M. disclose support for the research of this work from the University of Bristol and UK Medical Research Council (MC_UU_00032/5), the British Heart Foundation (AA/18/7/34219, CH/F/20/90003) and the European Research Council (101021566). J.R. discloses support for the research of this work from the European Union's Horizon 2020 (874739). E.K. discloses support for the research of this work from the Research Council of Finland and the Paeivikki and Sakari Sohlberg Foundation. M.V. discloses support for the research of this work from the Foundation for Diabetes Research, Yrjoe Jahnsson Foundation, Signe and Ane Gyllenberg Foundation, Suorsa Foundation and the Finnish Foundation for Cardiovascular Research. L.B. discloses support for the research of this work from the Fonds de recherche du Quebec - Sante (FRQS). P.E.J. discloses support for the research of this work from the Fonds de recherche du Quebec - Sante (FRQS). A.H.C., R.N.B. and R.M.F. disclose support for the research of this work from the Wellcome Trust (WT220390). A.E.H. discloses support for the research of this work from the National Institute for Health and Care Research (NIHR). M.V. discloses support for the research of this work from the Research Council of Norway (301178) and the University of Bergen. S.J. discloses support for the research of this work from Helse Vest (912250, F-12144), the Novo Nordisk Foundation (NNF19OC0057445) and the Research Council of Norway (315599). P.R.N. discloses support for the research of this work from the European Research Council (293574), Stiftelsen Kristian Gerhard Jebsen, Trond Mohn Foundation (TMS2022TMT01), the Research Council of Norway (240413), the Novo Nordisk Foundation (NNF18OC0054741), the University of Bergen and the Western Norway Regional Health Authority. A.E. discloses support for the research of this work from the Sarnoff Cardiovascular Research Foundation. E.W. discloses support for the research of this work from The Academy of Finland (352796). S.S., V.K. and A.H. disclose support for the research of this work from the European Union under Horizon Europe (101137146, 101137317, 101080250, 101080465 and 101057739) and Horizon 2020 (848158, 356888) and the Research Council of Finland (336449, 356888). A.P.M. discloses support for the research of this work from the Medical Research Council (MR/W029626/1), Versus Arthritis (21754) and the NIHR Manchester Biomedical Research Centre. L.C. discloses support for the research of this work from the European Union's Horizon 2020 (874739). All other authors declare no relevant funding.; https://hdl.handle.net/10138/634116; 105040779548; 001782195900002 |
| Διαθεσιμότητα: | https://hdl.handle.net/10138/634116 |
| Rights: | cc_by_nc_nd ; info:eu-repo/semantics/openAccess ; openAccess |
| Αριθμός Καταχώρησης: | edsbas.85C95D74 |
| Βάση Δεδομένων: | BASE |
| ISBN: | 9780017821959 0017821959 |
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