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Muhammed Nail Tekcan,1,* Fatih Balcı,2,* Oğuz Gündoğdu,3,* Onur Avcı3,* 1Department of Anesthesiology and Reanimation Kayseri City Hospital, Kayseri, Turkey; 2Department of Anesthesiology and Reanimation, Sivas Numune Hospital, Sivas, Turkey; 3Department of Anesthesiology and Reanimation, Cumhuriyet University School of Medicine, Sivas, Turkey*These authors contributed equally to this workCorrespondence: Fatih Balcı, Department of Anesthesiology and Reanimation, Sivas Numune Hospital, Sivas, Turkey, Tel +90 545 864 76 57, Email fatihbalci05@gmail.comPurpose: Effective postoperative pain management is essential following laparoscopic appendectomy. This exploratory pilot randomized controlled trial aimed to compare the postoperative analgesic efficacy of the transversus abdominis plane (TAP) block and the modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA) in patients undergoing laparoscopic appendectomy.Patients and Methods: This prospective, double-blind, single-center exploratory pilot randomized controlled trial included 30 adult patients (ASA I–III) scheduled for laparoscopic appendectomy due to uncomplicated acute appendicitis. Patients were randomly allocated to receive either bilateral TAP block (Group T, n = 15) or bilateral M-TAPA block (Group M, n = 15) under ultrasound guidance following induction of general anesthesia. Both groups received standardized multimodal analgesia. Postoperative pain intensity assessed by Numeric Rating Scale (NRS) was the primary outcome. Secondary outcomes included 24-hour tramadol consumption, Quality of Recovery-15 (QoR-15) scores, and adverse events. Pain assessments were performed at 1, 6, 12, 18, and 24 hours postoperatively by a blinded assessor.Results: All randomized patients completed the study. Demographic and clinical characteristics did not differ significantly between groups. Resting and dynamic NRS scores did not differ significantly between the TAP and M-TAPA groups at any postoperative time point (all p > 0.05). Median ... |