Academic Journal
The salivary metatranscriptome as an accurate diagnostic indicator of oral cancer
| Τίτλος: | The salivary metatranscriptome as an accurate diagnostic indicator of oral cancer |
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| Συγγραφείς: | Banavar, G, Ogundijo, O, Toma, R, Rajagopal, S, Lim, YK, Tang, K, Camacho, F, Torres, PJ, Gline, S, Parks, M, Kenny, L, Perlina, A, Tily, H, Dimitrova, N, Amar, S |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC |
| Έτος έκδοσης: | 2021 |
| Συλλογή: | Griffith University: Griffith Research Online |
| Θεματικοί όροι: | Oncology and carcinogenesis |
| Περιγραφή: | Despite advances in cancer treatment, the 5-year mortality rate for oral cancers (OC) is 40%, mainly due to the lack of early diagnostics. To advance early diagnostics for high-risk and average-risk populations, we developed and evaluated machine-learning (ML) classifiers using metatranscriptomic data from saliva samples (n = 433) collected from oral premalignant disorders (OPMD), OC patients (n = 71) and normal controls (n = 171). Our diagnostic classifiers yielded a receiver operating characteristics (ROC) area under the curve (AUC) up to 0.9, sensitivity up to 83% (92.3% for stage 1 cancer) and specificity up to 97.9%. Our metatranscriptomic signature incorporates both taxonomic and functional microbiome features, and reveals a number of taxa and functional pathways associated with OC. We demonstrate the potential clinical utility of an AI/ML model for diagnosing OC early, opening a new era of non-invasive diagnostics, enabling early intervention and improved patient outcomes. ; Full Text |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | npj Genomic Medicine; Banavar, G; Ogundijo, O; Toma, R; Rajagopal, S; Lim, YK; Tang, K; Camacho, F; Torres, PJ; Gline, S; Parks, M; Kenny, L; Perlina, A; Tily, H; Dimitrova, N; Amar, S; Vuyisich, M; Punyadeera, C, The salivary metatranscriptome as an accurate diagnostic indicator of oral cancer, npj Genomic Medicine, 2021, 6 (1), pp. 105; https://hdl.handle.net/10072/411341 |
| DOI: | 10.1038/s41525-021-00257-x |
| Διαθεσιμότητα: | https://hdl.handle.net/10072/411341 https://doi.org/10.1038/s41525-021-00257-x |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ; open access |
| Αριθμός Καταχώρησης: | edsbas.7B46AC24 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1038/s41525-021-00257-x |
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