Academic Journal
Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells
| Τίτλος: | Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells |
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| Συγγραφείς: | Huang, Ying, Jin, Minghua, Pi, Rongbiao, Zhang, Jun, Chen, Meihui, Ouyang, Ying, Liu, Anmin, Chao, Xiaojuan, Liu, Peiqing, Liu, Jun, Ramassamy, Charles, Qin, Jian |
| Συνεισφορές: | Sun Yat-sen University Guangzhou (SYSU), Armand-Frappier Santé Biotechnologie Research Centre (INRS-AFSB), Institut National de la Recherche Scientifique Québec (INRS)-Pasteur Network (Réseau International des Instituts Pasteur), This study was supported by Fundamental Research Funds for the Central Universities (No. 10ykpy23) and Guangdong Provincial International Cooperation Project of Science & Technology (No. 2012B050300015) to R. Pi and National Natural Science Foundation of China (No. 30371717) to J Qin. |
| Πηγή: | ISSN: 0304-3940. |
| Στοιχεία εκδότη: | CCSD Elsevier |
| Έτος έκδοσης: | 2013 |
| Συλλογή: | Réseau International des Instituts Pasteur, Paris: HAL-RIIP |
| Θεματικοί όροι: | Oxidative stress, Alzheimer's disease, Acrolein, Caffeic acid, MESH: ADAM Proteins/mCetabolismCell Line, MESH: Acrolein/toxicity, MESH: Glycogen Synthase Kinase 3/metabolism, MESH: Hippocampus/cytology, MESH: Hippocampus/drug effects, MESH: MAP Kinase Signaling System/drug effects, MESH: Membrane Proteins/metabolism, MESH: Mice, MESH: Neurons/cytology, MESH: Neurons/drug effects, MESH: Neuroprotective Agents/pharmacology, MESH: Oxidative Stress, MESH: Amyloid Precursor Protein, MESH: Phenylethyl Alcohol/analogs & derivatives, MESH: Proto-Oncogene Proteins c-akt/metabolism, MESH: Reactive Oxygen Species/metabolism, MESH: Secretases/metabolism, MESH: Animals, MESH: Antioxidants/pharmacology, MESH: Aspartic Acid Endopeptidases/metabolism, MESH: Caffeic Acids/pharmacology, MESH: Cell Survival/drug effects, MESH: Glutathione/metabolism, [SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology |
| Περιγραφή: | International audience ; Acrolein-induced oxidative stress is hypothesized to involve in the etiology of Alzheimer's disease (AD). Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) have antioxidative and neuroprotective properties. The present study investigated the protective effects of CA/CAPE on acrolein-induced oxidative neuronal toxicity. HT22 mouse hippocampal cells were pretreated with CA/CAPE and then exposed to acrolein. Cell viability, intracellular reactive oxygen species (ROS), and glutathione (GSH) level were measured. MAPKs and Akt/GSK3β signaling proteins as well as α/β-secretase of amyloid protein precursor were assayed by Western blotting. Pretreatment with CA/CAPE significantly attenuated acrolein-induced neurotoxicity, ROS accumulation, and GSH depletion. Further study suggested that CA/CAPE showed protective effects against acrolein by modulating MAPKs and Akt/GSK3β signaling pathways. Moreover, CA/CAPE restored the changes of β-secretase (BACE-1) and/or activation of α-secretase (ADAM-10) induced by acrolein. These findings suggest that CA/CAPE may provide a promising approach for the treatment of acrolein-related neurodegenerative diseases, such as AD. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/23313590; PUBMED: 23313590 |
| DOI: | 10.1016/j.neulet.2012.12.051 |
| Διαθεσιμότητα: | https://riip.hal.science/pasteur-01131056 https://doi.org/10.1016/j.neulet.2012.12.051 |
| Αριθμός Καταχώρησης: | edsbas.76190D1D |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1016/j.neulet.2012.12.051 |
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