Academic Journal
Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice
| Title: | Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice |
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| Authors: | Corthesy-Theulaz, I., Porta, N., Glauser, M., Saraga, E., Vaney, A. C., Haas, R., Kraehenbuhl, J. P., Blum, A. L., Michetti, P. |
| Publication Year: | 1995 |
| Collection: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Subject Terms: | Administration, Oral Animals Disease Models, Animal Female Helicobacter Infections/immunology/prevention & control/*therapy Helicobacter pylori/*enzymology *Immunotherapy Mice Mice, Inbred BALB C Recombinant Proteins/administration & dosage/therapeutic use Recurrence Urease/administration & dosage/*therapeutic use |
| Description: | BACKGROUND & AIMS: Eradication of Helicobacter pylori infections in humans results in the healing of gastritis and gastric ulcers. This study used a mouse model to test whether oral vaccination can cure Helicobacter infection and gastritis. METHODS: Mice were infected with Helicobacter felis. Three weeks after infection, the mice were orally immunized with H. pylori urease B subunit. Control mice were simultaneously infected but sham immunized. RESULTS: Three to 8 weeks after oral immunization of H. felis-infected mice with recombinant H. pylori urease B subunit, the infection cleared and there was no evidence of gastritis. Vaccinated mice remained protected against two consecutive H. felis challenges. CONCLUSIONS: These results show that the lack of natural immunity against Helicobacter can be overcome by oral immunization and that vaccination offers a novel therapeutic approach to Helicobacter-induced gastritis. |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| ISSN: | 0016-5085 |
| Relation: | Gastroenterology; https://iris.unil.ch/handle/iris/55882; serval:BIB_64F593FB886E; A1995RG19100013; 7797009 |
| DOI: | 10.1016/0016-5085(95)90275-9 |
| Availability: | https://iris.unil.ch/handle/iris/55882 https://doi.org/10.1016/0016-5085(95)90275-9 |
| Accession Number: | edsbas.75F4C0FA |
| Database: | BASE |
| ISSN: | 00165085 |
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| DOI: | 10.1016/0016-5085(95)90275-9 |