Academic Journal
Differences in clinical presentation and management between pre- and postsurgical diagnoses of urinary bladder paraganglioma: is there clinical relevance? A systematic review
| Τίτλος: | Differences in clinical presentation and management between pre- and postsurgical diagnoses of urinary bladder paraganglioma: is there clinical relevance? A systematic review |
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| Συγγραφείς: | Li, Minghao, Xu, Xiaowen, Bechmann, Nicole, Pamporaki, Christina, Jiang, Jingjing, Propping, Stefan, Liu, Longfei, Langenhuijsen, Johan F., Pacak, Karel, Eisenhofer, Graeme, Lenders, Jacques W. M. |
| Πηγή: | http://lobid.org/resources/99370672102306441#!, 40(2):385-390. |
| Έτος έκδοσης: | 2021 |
| Συλλογή: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| Θεματικοί όροι: | Urinary Bladder/pathology [MeSH], Humans [MeSH], Urinary bladder, Urinary Bladder Neoplasms/diagnosis [MeSH], Paraganglioma/diagnosis [MeSH], Urinary Bladder Neoplasms/pathology [MeSH], Hematuria [MeSH], Original Article, Urinary Bladder Neoplasms/surgery [MeSH], Cystectomy/methods [MeSH], Paraganglioma/pathology [MeSH], Paraganglioma, Paraganglioma/surgery [MeSH], Diagnosis, Treatment |
| Περιγραφή: | Purpose!#!Paraganglioma of the urinary bladder (UBPGL) is a rare neuroendocrine tumor diagnosed in many patients only after surgery. We, therefore, assessed clinical clues relevant to presurgical diagnosis and clinical consequences in patients with a missed presurgical diagnosis of UBPGL.!##!Materials and methods!#!Case reports describing a UBPGL (published from 1-1-2001 and 31-12-2020) were identified in Pubmed. Two authors independently performed data extraction and assessed data quality according to the PRISMA guideline. Patients were divided into two groups: UBPGL diagnosis before and after surgery.!##!Results!#!We included 177 articles reporting 194 cases. In 90 (46.4%) patients, the UBPGL was diagnosed before and in 104 (53.6%) after surgery. In presurgically diagnosed UBPGL, hypertension and catecholamine-associated symptoms were 2- to 3-fold (p < 0.001) more frequent than in postsurgically diagnosed patients whereas hematuria was twofold (p = 0.003) more prevalent in those with postsurgical diagnosis. Hypertension was an independent factor for presurgical biochemical testing (OR 4.45, 95% CI 1.66-11.94) while hematuria (OR 0.23, 95% CI 0.09-0.60) was an independent factor for not performing presurgical biochemical testing. Most patients diagnosed after surgery were not pretreated with alpha-adrenoceptor blockade (95.2%), underwent more frequently transurethral resection instead of cystectomy (70.2% vs. 23.1%) and had more frequent peroperative complications and residual tumor mass.!##!Conclusions!#!In nearly half of all patients with a UBPGL, the diagnosis was not established before surgery. Hypertension and hematuria contributed independently to a presurgical diagnosis. Postsurgical diagnosis, which was associated with suboptimal presurgical and surgical management, resulted in more peroperative complications and incomplete tumor resections. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | https://repository.publisso.de/resource/frl:6447691; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921018/ |
| DOI: | 10.1007/s00345-021-03851-x |
| Διαθεσιμότητα: | https://repository.publisso.de/resource/frl:6447691 https://doi.org/10.1007/s00345-021-03851-x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921018/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.71DE8CF5 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1007/s00345-021-03851-x |
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