Academic Journal
Seropositivity of Borrelia burgdorferi s.l. in Germany-an analysis across four German National Cohort (NAKO) study sites
| Τίτλος: | Seropositivity of Borrelia burgdorferi s.l. in Germany-an analysis across four German National Cohort (NAKO) study sites |
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| Συγγραφείς: | Hassenstein, M.J., Pischon, T., Karch, A., Peters, A., Kerrinnes, T., Teismann, H., Schneider, A., Thierry, S., Moreno Velásquez, I., Janke, J., Kemmling, Y., Castell, S. |
| Στοιχεία εκδότη: | Nature Publishing Group |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
| Θεματικοί όροι: | Cardiovascular and Metabolic Diseases, Technology Platforms, Topic 3: Integrative Biomedicine |
| Περιγραφή: | Lyme borreliosis (LB) is caused by the transmission of Borrelia burgdorferi s.l. from ticks to humans. Climate affects tick abundance, and climate change is projected to promote shifts in abundance in Europe, potentially increasing human exposure. We analyzed serum samples collected between the years 2014-2019 from German National Cohort (NAKO) participants at four study sites (Augsburg, Berlin, Hanover, Münster) for immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies using an enzyme-linked immunosorbent assay (ELISA) and line blot immunoassay as confirmatory test for positive and equivocal ELISA samples. We reported crude and weighted seropositivity proportions for local estimates. We used mixed model analysis to investigate associated factors, such as age, sex, migration background, or animal contacts. We determined the serostatus of 14,207 participants. The weighted seropositivity proportions were 3.4% (IgG) and 0.4% (IgM) in Augsburg, 4.1% (IgG) and 0.6% (IgM) in northern Berlin, 3.0% (IgG) and 0.9% (IgM) in Hanover, and 2.7% (IgG) and 0.6% (IgM) in Münster. We found higher odds for IgG seropositivity with advancing age (p < 0.001), among males compared to females (p < 0.001) and reduced odds among participants with migration background compared to those without (p = 0.001). We did not find evidence for an association between serostatus and depression, children within the household, or animal contact, respectively. We found low seropositivity proportions and indications of differences across the study locations, although between-group comparisons did not yield significant results. Comparisons to earlier research are subject to important limitations; however, our results indicate no major increases in seropositivity over time. Nevertheless, monitoring of seropositivity remains critical in light of potential climate-related Borrelia exposure. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf; other |
| Γλώσσα: | English |
| Relation: | https://edoc.mdc-berlin.de/id/eprint/23915/1/23915oa.pdf; https://edoc.mdc-berlin.de/id/eprint/23915/2/23915suppl.docx; Seropositivity of Borrelia burgdorferi s.l. in Germany-an analysis across four German National Cohort (NAKO) study sites. Hassenstein, M.J., Pischon, T., Karch, A., Peters, A., Kerrinnes, T., Teismann, H., Schneider, A., Thierry, S., Moreno Velásquez, I., Janke, J., Kemmling, Y. and Castell, S. Scientific Reports 13 (1): 21087. 30 November 2023; PMID:38036551; https://doi.org/10.1038/s41598-023-47766-6 |
| DOI: | 10.1038/s41598-023-47766-6 |
| Διαθεσιμότητα: | https://edoc.mdc-berlin.de/id/eprint/23915/ https://edoc.mdc-berlin.de/23915/ https://doi.org/10.1038/s41598-023-47766-6 |
| Rights: | cc_by_4 |
| Αριθμός Καταχώρησης: | edsbas.6AF4B2A9 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1038/s41598-023-47766-6 |
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