Dataset
Riboflavin-Vancomycin Conjugate Enables Simultaneous Antibiotic Photo-Release and Photodynamic Killing against Resistant Gram-Positive Pathogens
| Τίτλος: | Riboflavin-Vancomycin Conjugate Enables Simultaneous Antibiotic Photo-Release and Photodynamic Killing against Resistant Gram-Positive Pathogens |
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| Συγγραφείς: | Klausen, Maxime, Mills, Bethany, Kiang, Alex, Mohanan, Syam Mohan P.C., Dhaliwal, Kevin, Bradley, Mark |
| Συνεισφορές: | EPSRC - Engineering and Physical Sciences Research Council, Klausen, Maxime |
| Στοιχεία εκδότη: | University of Edinburgh. School of Chemistry |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | Edinburgh DataShare (University of Edinburgh) |
| Θεματικοί όροι: | photodynamic therapy, photolabile protecting groups, uncaging, antimicrobial resistance, antibiotic, ESKAPE pathogens |
| Θέμα γεωγραφικό: | UK, UNITED KINGDOM |
| Περιγραφή: | This dataset was used in the analysis of a new light-activated molecule, VanB2, based on conjugation of the FDA-approved photosensitizer riboflavin to the Gram-positive specific ligand vancomycin for targeted antimicrobial photodynamic therapy. The riboflavin-vancomycin conjugate proved to be a potent and versatile antibacterial agent, enabling the rapid, light-mediated, killing of MRSA and VRE with no significant off-target effects. The attachment of riboflavin on vancomycin also led to an increased in antibiotic activity against S. aureus and VRE. Simultaneously, we evidenced that the flavin sub-unit undergoes an efficient photo-induced bond cleavage reaction to release vancomycin, thereby acting as a photo-removable protecting group for drug-delivery. This dataset is related to the upcoming article "Riboflavin-Vancomycin Conjugate Enables Simultaneous Antibiotic Photo-Release and Photodynamic Killing against Resistant Gram-Positive Pathogens" by B. Mills, A. Kiang, S. M. P. C. Mohanan, M. Bradley, K. Dhaliwal and M. Klausen (submitted to ChemRxiv). |
| Τύπος εγγράφου: | dataset |
| Περιγραφή αρχείου: | application/vnd.openxmlformats-officedocument.spreadsheetml.sheet; text/plain |
| Γλώσσα: | English |
| Relation: | https://hdl.handle.net/10283/4859; https://doi.org/10.7488/ds/3852 |
| DOI: | 10.7488/ds/3852 |
| Διαθεσιμότητα: | https://hdl.handle.net/10283/4859 https://doi.org/10.7488/ds/3852 |
| Rights: | Creative Commons Attribution 4.0 International Public License |
| Αριθμός Καταχώρησης: | edsbas.6A46BEDB |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.7488/ds/3852 |
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