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Corticosteroid-Antibiotic Interactions in Bacteria that Cause Corneal Infection

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Title: Corticosteroid-Antibiotic Interactions in Bacteria that Cause Corneal Infection
Contributors: Hun Lee, So Myoung Kim, Md Intazur Rahaman, Dong Ju Kang, Changhyun Kim, Tae-Im Kim, So Won Kim, Kim, Tae Im
Publisher Information: Association for Research in Vision and Ophthalmology
Publication Year: 2023
Subject Terms: Adrenal Cortex Hormones / pharmacology, Adrenal Cortex Hormones / therapeutic use, Anti-Bacterial Agents / pharmacology, Anti-Bacterial Agents / therapeutic use, Bacteria, Dexamethasone / pharmacology, Dexamethasone / therapeutic use, Drug Combinations, Eye Infections, Bacterial* / drug therapy, Bacterial* / microbiology, Fluorometholone / pharmacology, Fluorometholone / therapeutic use, Humans, Keratitis* / drug therapy, Levofloxacin / pharmacology, Levofloxacin / therapeutic use, Prednisolone / pharmacology, Prednisolone / therapeutic use, Tobramycin / pharmacology, Tobramycin / therapeutic use
Description: Purpose: Although a comprehensive knowledge of antibiotic/corticosteroid combinations is essential for the appropriate treatment of eye infections, the impact of their co-administration has not been well studied to date. A systematic pharmacodynamic/pharmacokinetic study to determine the effects of cotreatment with various antibiotics and corticosteroids was conducted. Methods: Four bacterial strains, seven antibiotics, and four corticosteroids were used in the analyses. Drug interactions were evaluated by considering antibacterial effects with a checkerboard assay and intracellular concentrations in human corneal epithelial cells. Results: The drug combinations that showed the most stable effects against Pseudomonas aeruginosa was levofloxacin-prednisolone. Stable combinations against the three types of Gram-positive bacteria were neomycin-prednisolone, ofloxacin-dexamethasone, ofloxacin-prednisolone, and polymyxin-dexamethasone. The cellular concentrations were changed for the gatifloxacin-fluorometholone, moxifloxacin-fluorometholone, tobramycin-dexamethasone, and tobramycin-prednisolone combinations. Conclusions: Loteprednol and fluorometholone reduced the antibacterial effects of all of the tested antibiotics in this study. Dexamethasone and prednisolone showed various effects in this regard, depending on the co-administered antibiotic. Prior knowledge of specific antibiotic/corticosteroid interactions provides valuable information to clinical practitioners by combining data on the antibacterial and intracellular uptake effects of their co-administration. Translational relevance: When using antibiotics and corticosteroids, drug combinations can be selected by referring to the results of this study. ; open
Document Type: article in journal/newspaper
Language: English
Relation: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY; J04101; https://ir.ymlib.yonsei.ac.kr/handle/22282913/195495; T202303366
DOI: 10.1167/tvst.12.5.16
Availability: https://ir.ymlib.yonsei.ac.kr/handle/22282913/195495
https://doi.org/10.1167/tvst.12.5.16
Rights: CC BY-NC-ND 2.0 KR
Accession Number: edsbas.64FA5871
Database: BASE
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  – Url: https://ir.ymlib.yonsei.ac.kr/handle/22282913/195495#
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Corticosteroid-Antibiotic Interactions in Bacteria that Cause Corneal Infection
– Name: Author
  Label: Contributors
  Group: Au
  Data: Hun Lee<br />So Myoung Kim<br />Md Intazur Rahaman<br />Dong Ju Kang<br />Changhyun Kim<br />Tae-Im Kim<br />So Won Kim<br />Kim, Tae Im
– Name: Publisher
  Label: Publisher Information
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  Data: Association for Research in Vision and Ophthalmology
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2023
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Adrenal+Cortex+Hormones+%2F+pharmacology%22">Adrenal Cortex Hormones / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Adrenal+Cortex+Hormones+%2F+therapeutic+use%22">Adrenal Cortex Hormones / therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-Bacterial+Agents+%2F+pharmacology%22">Anti-Bacterial Agents / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-Bacterial+Agents+%2F+therapeutic+use%22">Anti-Bacterial Agents / therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Bacteria%22">Bacteria</searchLink><br /><searchLink fieldCode="DE" term="%22Dexamethasone+%2F+pharmacology%22">Dexamethasone / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Dexamethasone+%2F+therapeutic+use%22">Dexamethasone / therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+Combinations%22">Drug Combinations</searchLink><br /><searchLink fieldCode="DE" term="%22Eye+Infections%22">Eye Infections</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial*+%2F+drug+therapy%22">Bacterial* / drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial*+%2F+microbiology%22">Bacterial* / microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorometholone+%2F+pharmacology%22">Fluorometholone / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorometholone+%2F+therapeutic+use%22">Fluorometholone / therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Keratitis*+%2F+drug+therapy%22">Keratitis* / drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Levofloxacin+%2F+pharmacology%22">Levofloxacin / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Levofloxacin+%2F+therapeutic+use%22">Levofloxacin / therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Prednisolone+%2F+pharmacology%22">Prednisolone / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Prednisolone+%2F+therapeutic+use%22">Prednisolone / therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Tobramycin+%2F+pharmacology%22">Tobramycin / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Tobramycin+%2F+therapeutic+use%22">Tobramycin / therapeutic use</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Purpose: Although a comprehensive knowledge of antibiotic/corticosteroid combinations is essential for the appropriate treatment of eye infections, the impact of their co-administration has not been well studied to date. A systematic pharmacodynamic/pharmacokinetic study to determine the effects of cotreatment with various antibiotics and corticosteroids was conducted. Methods: Four bacterial strains, seven antibiotics, and four corticosteroids were used in the analyses. Drug interactions were evaluated by considering antibacterial effects with a checkerboard assay and intracellular concentrations in human corneal epithelial cells. Results: The drug combinations that showed the most stable effects against Pseudomonas aeruginosa was levofloxacin-prednisolone. Stable combinations against the three types of Gram-positive bacteria were neomycin-prednisolone, ofloxacin-dexamethasone, ofloxacin-prednisolone, and polymyxin-dexamethasone. The cellular concentrations were changed for the gatifloxacin-fluorometholone, moxifloxacin-fluorometholone, tobramycin-dexamethasone, and tobramycin-prednisolone combinations. Conclusions: Loteprednol and fluorometholone reduced the antibacterial effects of all of the tested antibiotics in this study. Dexamethasone and prednisolone showed various effects in this regard, depending on the co-administered antibiotic. Prior knowledge of specific antibiotic/corticosteroid interactions provides valuable information to clinical practitioners by combining data on the antibacterial and intracellular uptake effects of their co-administration. Translational relevance: When using antibiotics and corticosteroids, drug combinations can be selected by referring to the results of this study. ; open
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  Data: article in journal/newspaper
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  Data: English
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  Label: Relation
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  Data: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY; J04101; https://ir.ymlib.yonsei.ac.kr/handle/22282913/195495; T202303366
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1167/tvst.12.5.16
– Name: URL
  Label: Availability
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  Data: https://ir.ymlib.yonsei.ac.kr/handle/22282913/195495<br />https://doi.org/10.1167/tvst.12.5.16
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  Data: CC BY-NC-ND 2.0 KR
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  Data: edsbas.64FA5871
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RecordInfo BibRecord:
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        Value: 10.1167/tvst.12.5.16
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Adrenal Cortex Hormones / pharmacology
        Type: general
      – SubjectFull: Adrenal Cortex Hormones / therapeutic use
        Type: general
      – SubjectFull: Anti-Bacterial Agents / pharmacology
        Type: general
      – SubjectFull: Anti-Bacterial Agents / therapeutic use
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      – SubjectFull: Bacteria
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      – SubjectFull: Dexamethasone / pharmacology
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      – SubjectFull: Dexamethasone / therapeutic use
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      – SubjectFull: Drug Combinations
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      – SubjectFull: Eye Infections
        Type: general
      – SubjectFull: Bacterial* / drug therapy
        Type: general
      – SubjectFull: Bacterial* / microbiology
        Type: general
      – SubjectFull: Fluorometholone / pharmacology
        Type: general
      – SubjectFull: Fluorometholone / therapeutic use
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      – SubjectFull: Humans
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      – SubjectFull: Keratitis* / drug therapy
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      – SubjectFull: Levofloxacin / pharmacology
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      – SubjectFull: Levofloxacin / therapeutic use
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      – SubjectFull: Prednisolone / pharmacology
        Type: general
      – SubjectFull: Prednisolone / therapeutic use
        Type: general
      – SubjectFull: Tobramycin / pharmacology
        Type: general
      – SubjectFull: Tobramycin / therapeutic use
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      – TitleFull: Corticosteroid-Antibiotic Interactions in Bacteria that Cause Corneal Infection
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            NameFull: Hun Lee
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              Type: published
              Y: 2023
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