Academic Journal
Corticosteroid-Antibiotic Interactions in Bacteria that Cause Corneal Infection
| Τίτλος: | Corticosteroid-Antibiotic Interactions in Bacteria that Cause Corneal Infection |
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| Συνεισφορές: | Hun Lee, So Myoung Kim, Md Intazur Rahaman, Dong Ju Kang, Changhyun Kim, Tae-Im Kim, So Won Kim, Kim, Tae Im |
| Στοιχεία εκδότη: | Association for Research in Vision and Ophthalmology |
| Έτος έκδοσης: | 2023 |
| Θεματικοί όροι: | Adrenal Cortex Hormones / pharmacology, Adrenal Cortex Hormones / therapeutic use, Anti-Bacterial Agents / pharmacology, Anti-Bacterial Agents / therapeutic use, Bacteria, Dexamethasone / pharmacology, Dexamethasone / therapeutic use, Drug Combinations, Eye Infections, Bacterial* / drug therapy, Bacterial* / microbiology, Fluorometholone / pharmacology, Fluorometholone / therapeutic use, Humans, Keratitis* / drug therapy, Levofloxacin / pharmacology, Levofloxacin / therapeutic use, Prednisolone / pharmacology, Prednisolone / therapeutic use, Tobramycin / pharmacology, Tobramycin / therapeutic use |
| Περιγραφή: | Purpose: Although a comprehensive knowledge of antibiotic/corticosteroid combinations is essential for the appropriate treatment of eye infections, the impact of their co-administration has not been well studied to date. A systematic pharmacodynamic/pharmacokinetic study to determine the effects of cotreatment with various antibiotics and corticosteroids was conducted. Methods: Four bacterial strains, seven antibiotics, and four corticosteroids were used in the analyses. Drug interactions were evaluated by considering antibacterial effects with a checkerboard assay and intracellular concentrations in human corneal epithelial cells. Results: The drug combinations that showed the most stable effects against Pseudomonas aeruginosa was levofloxacin-prednisolone. Stable combinations against the three types of Gram-positive bacteria were neomycin-prednisolone, ofloxacin-dexamethasone, ofloxacin-prednisolone, and polymyxin-dexamethasone. The cellular concentrations were changed for the gatifloxacin-fluorometholone, moxifloxacin-fluorometholone, tobramycin-dexamethasone, and tobramycin-prednisolone combinations. Conclusions: Loteprednol and fluorometholone reduced the antibacterial effects of all of the tested antibiotics in this study. Dexamethasone and prednisolone showed various effects in this regard, depending on the co-administered antibiotic. Prior knowledge of specific antibiotic/corticosteroid interactions provides valuable information to clinical practitioners by combining data on the antibacterial and intracellular uptake effects of their co-administration. Translational relevance: When using antibiotics and corticosteroids, drug combinations can be selected by referring to the results of this study. ; open |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | TRANSLATIONAL VISION SCIENCE & TECHNOLOGY; J04101; https://ir.ymlib.yonsei.ac.kr/handle/22282913/195495; T202303366 |
| DOI: | 10.1167/tvst.12.5.16 |
| Διαθεσιμότητα: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195495 https://doi.org/10.1167/tvst.12.5.16 |
| Rights: | CC BY-NC-ND 2.0 KR |
| Αριθμός Καταχώρησης: | edsbas.64FA5871 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1167/tvst.12.5.16 |
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