Bibliographic Details
| Title: |
The impact of age on survival and excess mortality after autologous hematopoietic cell transplantation in newly diagnosed multiple myeloma patients |
| Authors: |
Mizuno, S., Gras, L., Baaij, L.G.A., Koster, L., D'Souza, A., Hari, P.N., Estrada-Merly, N., Saber, W., Cowan, A.J., Iida, M., Okamoto, S., Takamatsu, H., Kawamura, K., Kodera, Y., Hamad, N., Ko, B.-S., Liam, C., Ho, K.W., Goh, A.S., Keat, T.S., Elhaddad, A.M., Bazarbachi, A., Chaudhry, B.Q.U.N., Alfar, R., Bekadja, M.A., Benakli, M., Ortiz, C.A.F., Riva, E., Verburgh, E., Galeano, S., Bass, F., Mian, H., McCurdy, A., Wang, F.R., Neumann, D., Koh, M.B.C., Snowden, J.A., Schönland, S., McLornan, D.P., Hayden, P.J., Balari, A.M.S., Greinix, H.T., Aljurf, M., Atsuta, Y., Rondelli, D., Niederwieser, D.W., Garderet, L. |
| Publisher Information: |
Ferrata Storti Foundation (Haematologica) |
| Publication Year: |
2026 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Despite the availability of novel agents, autologous hematopoietic cell transplantation (auto-HCT) remains the standard of care in newly diagnosed multiple myeloma (MM) patients. The impact of age on overall survival (OS), progression-free survival (PFS), relapse incidence, non-relapse mortality (NRM), and excess mortality (taking account of general population mortality) was investigated using information on 61,797 MM patients transplanted between 2013 and 2017. The median age at auto-HCT was 60.8 (range: 18.1–83.2) years of whom 2.0% were 18–39 years, 68.9% 40–64 years, 21.8% 65–69 years, 6.5% 70–74 years, and 0.8% ≥75 years of age, respectively. The corresponding OS probabilities at three years were 85.9%, 82.8%, 81.1%, 78.4%, and 74.8%, respectively (p<0.001). Excess mortality cumulative incidences were 13.1%, 15.0%, 14.6%, 15.0%, and 14.1% at three years, respectively (p=0.67). In multivariable analyses, older age was a significant risk factor for OS, PFS, and NRM but not for excess mortality or relapse risk. Our results indicate that advanced age alone should not preclude the use of auto-HCT in patients with MM. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
0390-6078 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/230842/8/12198-Article%20Text-88204-2-10-20251211.pdf; Mizuno, S., Gras, L., Baaij, L.G.A. et al. (44 more authors) (2026) The impact of age on survival and excess mortality after autologous hematopoietic cell transplantation in newly diagnosed multiple myeloma patients. Haematologica, 111 (1). pp. 286-299. ISSN: 0390-6078 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/230842/ |
| Rights: |
cc_by_nc_4 |
| Accession Number: |
edsbas.61276F02 |
| Database: |
BASE |