Academic Journal
Complete genome sequence of Porphyromonas gingivalis strain KCOM 2796 isolated from subgingival plaque of a patient with periodontitis
| Τίτλος: | Complete genome sequence of Porphyromonas gingivalis strain KCOM 2796 isolated from subgingival plaque of a patient with periodontitis |
|---|---|
| Συγγραφείς: | Lim, YK, Park, SN, Ji, S, Kook, JK |
| Συνεισφορές: | 110562, Ji, S |
| Έτος έκδοσης: | 2026 |
| Θεματικοί όροι: | complete genome, periodontitis, Porphyromonas gingivalis, virulence factors |
| Περιγραφή: | Porphyromonas gingivalis is a major periodontal pathogen, and understanding its genetic diversity in the Korean population is crucial for elucidating pathogenic mechanisms. We report the complete genome sequence of P. gingivalis strain JS1 (KCOM 2796), isolated from subgingival dental plaque of a patient with periodontitis. The complete genome was sequenced using a hybrid approach combining PacBio RSII and Illumina HiSeq platforms, resulting in a single circular chromosome of 2,476,166 bp. Phylogenetic analysis based on 16S rRNA gene sequence showed 99.25% similarity with P. gingivalis ATCC 33277T, and the orthologous average nucleotide identity value was 98.35% and digital DNA-DNA hybridization value was 85.2%, confirming its identification as P. gingivalis. Genome annotation revealed 2,213 genes, including 2,016 protein-coding genes and 67 RNA genes, with 130 pseudogenes and two CRISPR arrays. Virulence factor analysis identified multiple extracellular proteases involved in tissue invasion and host cell damage. The genomic information of strain KCOM 2796 provides important foundational data for understanding the pathogenesis and genetic diversity of P. gingivalis strains in the Korean population. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | J004402413; http://repository.ajou.ac.kr/handle/201003/36985 |
| DOI: | 10.7845/kjm.2026.5070 |
| Διαθεσιμότητα: | http://repository.ajou.ac.kr/handle/201003/36985 https://doi.org/10.7845/kjm.2026.5070 |
| Αριθμός Καταχώρησης: | edsbas.60655D90 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.7845/kjm.2026.5070 |
|---|