Academic Journal
The effects of transcutaneous spinal cord stimulation delivered with and without high-frequency modulation on spinal and corticospinal excitability
| Τίτλος: | The effects of transcutaneous spinal cord stimulation delivered with and without high-frequency modulation on spinal and corticospinal excitability |
|---|---|
| Συγγραφείς: | Massey, S, Konig, D, Upadhyay, P, Evcil, ZB, Melin, R, Fatima, M, Hannah, R, Duffell, L |
| Πηγή: | Artificial Organs (2023) (In press). |
| Στοιχεία εκδότη: | Wiley |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | University College London: UCL Discovery |
| Θεματικοί όροι: | Corticospinal excitability, spinal cord injury, spinal cord stimulation |
| Περιγραφή: | Transcutaneous spinal cord stimulation (TSCS) has been shown to improve motor recovery in people with spinal cord injury (SCI). Some groups deliver TSCS modulated with a kHz-frequency (TSCS–kHz); the intensity used for TSCS–kHz is usually set based on the motor threshold for TSCS, even though TSCS–kHz threshold is considerably higher than TSCS. As a result, TSCS–kHz interventions tend to be delivered at low intensities with respect to the motor threshold (~40%). In this study, we compared the effects of sub-threshold TSCS and TSCS–kHz, when delivered at similar intensity relative to their own motor threshold. Experiment I compared the after-effects of 20 min of sub-threshold (40% threshold) TSCS and TSCS–kHz on spinal and corticospinal excitability in able-bodied participants. Experiment II assessed the dose–response relationship of delivering short (10-pulse) trains of TSCS and TSCS–kHz at three different current intensities relative to the threshold (40%, 60%, and 80%). Experiment I found that 20 min of TSCS–kHz at a 40% threshold decreased posterior root reflex amplitude (p < 0.05), whereas TSCS did not. In experiment II, motor-evoked potential (MEP) amplitude increased following short trains of TSCS and TSCS–kHz of increasing intensity. MEP amplitude was significantly greater for TSCS–kHz compared with TSCS when delivered at 80% of the threshold (p < 0.05). These results suggest that TSCS and TSCS–kHz have different effects when delivered at similar intensity relative to their own threshold; both for immediate effects on corticospinal excitability and following prolonged stimulation on spinal excitability. These different effects may be utilized for optimal rehabilitation in people with SCI. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10179808/ |
| Διαθεσιμότητα: | https://discovery.ucl.ac.uk/id/eprint/10179808/1/Artificial%20Organs%20-%202023%20-%20Massey%20-%20The%20effects%20of%20transcutaneous%20spinal%20cord%20stimulation%20delivered%20with%20and%20without.pdf https://discovery.ucl.ac.uk/id/eprint/10179808/ |
| Rights: | open |
| Αριθμός Καταχώρησης: | edsbas.5A612E1E |
| Βάση Δεδομένων: | BASE |
| Η περιγραφή δεν είναι διαθέσιμη |