Academic Journal
The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium
| Τίτλος: | The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium |
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| Συγγραφείς: | Dabo, B, Pelucchi, C, Rota, M, Jain, H, Bertuccio, P, Bonzi, R, Palli, D, Ferraroni, M, Zhang, Z-F, Sanchez-Anguiano, A, Thi-Hai, Pham, Y, Thi-Du Tran, C, Gia Pham, A, Yu, G-P, Nguyen, TC, Muscat, J, Tsugane, S, Hidaka, A, Hamada, GS, Zaridze, D, Maximovitch, D, Kogevinas, M, Fernàndez De Larrea, N, Boccia, S, Pastorino, R, Kurtz, RC, Lagiou, A, Lagiou, P, Vioque, J, Camargo, MC, Paula Curado, M, Lunet, N, Boffetta, P, Negri, E, La Vecchia, C, Luu, HN |
| Συνεισφορές: | Instituto de Saúde Pública da Universidade do Porto |
| Στοιχεία εκδότη: | Lippincott Williams and Wilkins |
| Έτος έκδοσης: | 2022 |
| Συλλογή: | Repositório Aberto da Universidade do Porto |
| Θεματικοί όροι: | diabetes, gastric cancer, risk factors |
| Περιγραφή: | Background Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. Objective To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of more than 30 case-control and nested case-control studies, which is large and provides harmonized definition of participants' characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis. Methods We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs. Results We did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94-1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02-1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls. Conclusion This study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk. © 2022 Lippincott Williams and Wilkins. All rights reserved. ; This work was supported by Associazione Italiana per la Ricerca sul Cancro (AIRC), Project no. 21378 (Investigator Grant); Fondazione Italiana per la Ricerca sul Cancro (FIRC); Italian League for the Fight Against Cancer (LILT); European Cancer ... |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | Eur J Cancer Prev. 2022 May 1;31(3):260-269. doi:10.1097/CEJ.0000000000000703.; https://journals.lww.com/eurjcancerprev/Fulltext/2022/05000/The_association_between_diabetes_and_gastric.6.aspx; https://hdl.handle.net/10216/151567 |
| DOI: | 10.1097/CEJ.0000000000000703 |
| Διαθεσιμότητα: | https://hdl.handle.net/10216/151567 https://doi.org/10.1097/CEJ.0000000000000703 |
| Rights: | info:eu-repo/semantics/openAccess |
| Αριθμός Καταχώρησης: | edsbas.59744854 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1097/CEJ.0000000000000703 |
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