Academic Journal
Estimated glomerular filtration rate, albuminuria, and adverse outcomes: an individual-participant data meta-analysis
| Τίτλος: | Estimated glomerular filtration rate, albuminuria, and adverse outcomes: an individual-participant data meta-analysis |
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| Συγγραφείς: | Grams, M.E., Coresh, J., Matsushita, K., Ballew, S.H., Sang, Y.Y., Surapaneni, A., Pinho, N.A. de, Anderson, A., Appel, L.J., Ärnlöv, J., Azizi, F., Bansal, N., Bell, S., Bilo, H.J.G., Brunskill, N.J., Carrero, J.J., Chadban, S., Chalmers, J., Chen, J., Ciemins, E., Cirillo, M., Ebert, N., Evans, M., Ferreiro, A., Fu, E.L., Fukagawa, M., Green, J.A., Gutierrez, O.M., Herrington, W.G., Hwang, S.J., Inker, L.A., Iseki, K., Jafar, T., Jassal, S.K., Jha, V., Kadota, A., Katz, R., Köttgen, A., Konta, T., Kronenberg, F., Lee, B.J., Lees, J., Levin, A., Looker, H.C., Major, R., Cohen, C.M., Mieno, M., Miyazaki, M., Moranne, O., Muraki, I., Naimark, D., Nitsch, D., Oh, W., Pena, M., Purnell, T.S., Sabanayagam, C., Satoh, M., Sawhney, S., Schaeffner, E., Schöttker, B., Shen, J.I., Shlipak, M.G., Sinha, S., Stengel, B., Sumida, K., Tonelli, M., Valdivielso, J.M., Zuilen, A.D. van, Visseren, F.L.J., Wang, A.Y.M., Wen, C.P., Wheeler, D.C., Yatsuya, H., Yamagata, K., Yang, J.W., Young, A., Zhang, H.T., Zhang, L., Levey, A.S., Gansevoort, R.T., Writing Grp CKD Prognosis Consorti |
| Πηγή: | Journal of the American Medical Association |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | Leiden Repository (Leiden University) |
| Περιγραφή: | IMPORTANCE Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US.OBJECTIVE To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes.DESIGN, SETTING, AND PARTICIPANTS Individual-participant data meta-analysis of 27 503 140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720 736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9 067 753 individuals from 114 cohorts (albuminuria) from 1980 to 2021.EXPOSURES The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR based on creatinine alone and eGFR based on creatinine and cystatin C; and albuminuria estimated as urine albumin to creatinine ratio (UACR).MAIN OUTCOMES AND MEASURES The risk of kidney failure requiring replacement therapy, all-cause mortality, cardiovascular mortality, acute kidney injury, any hospitalization, coronary heart disease, stroke, heart failure, atrial fibrillation, and peripheral artery disease. The analyses were performed within each cohort and summarized with random-effects meta-analyses.RESULTS Within the population using eGFR based on creatinine alone (mean age, 54 years [SD, 17 years]; 51% were women; mean follow-up time, 4.8 years [SD, 3.3 years]), the mean eGFR was 90 mL/min/1.73m(2) (SD, 22 mL/min/1.73m(2)) and the median UACR was 11mg/g (IQR, 8-16mg/g). Within the population using eGFR based on creatinine and cystatin C (mean age, 59 years [SD, 12 years]; 53% were women; mean follow-up time, 10.8 years [SD, 4.1 years]), the mean eGFR was 88 mL/min/1.73m(2) (SD, 22 mL/min/1.73m(2)) and the median UACR was 9mg/g (IQR, 6-18mg/g). Lower eGFR (whether based on creatinine alone or based on creatinine and cystatin C) and higher UACR were each significantly associated with higher risk for each of the 10 adverse outcomes, ... |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | https://jamanetwork.com/journals/jama/fullarticle/2810033; https://hdl.handle.net/1887/3729556 |
| DOI: | 10.1001/jama.2023.17002 |
| Διαθεσιμότητα: | https://hdl.handle.net/1887/3729556 https://jamanetwork.com/journals/jama/fullarticle/2810033 https://doi.org/10.1001/jama.2023.17002 |
| Αριθμός Καταχώρησης: | edsbas.53ED20A0 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1001/jama.2023.17002 |
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