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Retrospective longitudinal study on the long-term impact of COVID-19 infection on polysomnographic evaluation in patients with Prader-Willi syndrome

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Retrospective longitudinal study on the long-term impact of COVID-19 infection on polysomnographic evaluation in patients with Prader-Willi syndrome
Συγγραφείς: Braun, Sina, Laemmer, Constanze, Schulte, Sandra, Gohlke, Bettina
Πηγή: http://lobid.org/resources/99370675069506441#!, 19(1):461.
Έτος έκδοσης: 2024
Συλλογή: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
Θεματικοί όροι: COVID-19, Adolescent [MeSH], Female [MeSH], Polysomnography/methods [MeSH], COVID-19 sequelae, Prader-Willi Syndrome/physiopathology [MeSH], Adult [MeSH], Polysomnography, Humans [MeSH], Longitudinal Studies [MeSH], Retrospective Studies [MeSH], Prader-Willi syndrome, Male [MeSH], Research, Long COVID, Young Adult [MeSH], COVID-19/epidemiology [MeSH], Child [MeSH], SARS-CoV-2 [MeSH], Child, Preschool [MeSH]
Περιγραφή: Abstract Background To evaluate the impact of coronavirus disease 2019 (COVID-19) on polysomnographic evaluation in patients with Prader-Willi syndrome (PWS). Patients and methods A retrospective cohort study of two consecutive overnight polysomnograms (PSG) in 92 PWS patients (mean age 9.1, range 3.1–22 years). 57/92 participants (35 female) had a COVID-19 infection between the two consecutive examinations. 35 patients (21 female) had no infection (control group). Distribution of genetics was as follows: 13/57 (22.8%) deletion, 19/57 (33.3%) uniparental disomy, 2/57 (3,5%) imprinting defect, 3/57 (5.3%) non-deletion, 20/57 (35.1%) diagnosed by analyses of the methylation pattern of chromosome 15q11-13. Mean time interval between COVID-19 infection and post-COVID-19 evaluation was 96.2 days. Results Course of COVID-19 infection was asymptomatic 8/82 (9.8%), mild 63/82 (76.8%), medium 11/84 (13.4%). The five most frequently experienced symptoms in PWS patients were fever (56.1%); headache (45.1%); cold (42.7%); cough (31.7%) and body aches (21.95%). PWS patients who had COVID-19 infection had significantly lower mean oxygen saturation (SpO2) measured by pulse oximetry (post 94.8% vs. pre 95.7%, p = 0.001), lower detected lowermost SpO2 (post 86.2 vs. pre 87.3%, p = 0.003), and higher occurrence of hypopnoea (post 13.9 vs. pre 10.7, p = 0.001). Time in optimal SpO2 (95–100%) decreased significantly (post 54.3% vs. pre 73.8%, p = 0.001), whereas an increase was observed in time in suboptimal SpO2 (90–95%) (post 45.5% vs. 25.8%, ...
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: https://repository.publisso.de/resource/frl:6523214; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639118/
DOI: 10.1186/s13023-024-03447-9
Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6523214
https://doi.org/10.1186/s13023-024-03447-9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639118/
Rights: https://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης: edsbas.51AEBFC
Βάση Δεδομένων: BASE
Περιγραφή
DOI:10.1186/s13023-024-03447-9