Academic Journal
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
| Τίτλος: | Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission |
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| Συγγραφείς: | Aggarwal, D, Warne, B, Jahun, AS, Hamilton, WL, Fieldman, T, du Plessis, L, Hill, V, Blane, B, Watkins, E, Wright, E, Hall, G, Ludden, C, Myers, R, Hosmillo, M, Chaudhry, Y, Pinckert, ML, Georgana, I, Izuagbe, R, Leek, D, Nsonwu, O, Hughes, GJ, Packer, S, Page, AJ, Metaxaki, M, Fuller, S, Weale, G, Holgate, J, Brown, CA, Howes, R, McFarlane, D, Dougan, G, Pybus, OG, Angelis, DD, Maxwell, PH, Peacock, SJ, Weekes, MP, Illingworth, C, Harrison, EM, Matheson, NJ, Goodfellow, IG |
| Στοιχεία εκδότη: | Nature Research |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | Oxford University Research Archive (ORA) |
| Περιγραφή: | Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| DOI: | 10.1038/s41467-021-27942-w |
| Διαθεσιμότητα: | https://doi.org/10.1038/s41467-021-27942-w https://ora.ox.ac.uk/objects/uuid:6c05292f-175e-4f15-a2eb-5e52b894b3b1 |
| Rights: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Αριθμός Καταχώρησης: | edsbas.49489BC5 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1038/s41467-021-27942-w |
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