Academic Journal
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
| Τίτλος: | Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission |
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| Συγγραφείς: | Rivett, L, Sridhar, S, Sparkes, D, Routledge, M, Jones, NK, Forrest, S, Young, J, Pereira-Dias, J, Hamilton, WL, Ferris, M, Torok, ME, Meredith, L, Collaboration, CITIID-NIHR COVID-19 BioResource, Curran, MD, Fuller, S, Chaudhry, A, Shaw, A, Samworth, RJ, Bradley, JR, Dougan, G, Smith, KG, Lehner, PJ, Matheson, NJ, Wright, G, Goodfellow, IG, Baker, S, Weekes, MP |
| Στοιχεία εκδότη: | eLife Sciences Publications |
| Έτος έκδοσης: | 2021 |
| Συλλογή: | Oxford University Research Archive (ORA) |
| Περιγραφή: | Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19)>7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B∙1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | https://doi.org/10.7554/elife.58728 |
| DOI: | 10.7554/elife.58728 |
| Διαθεσιμότητα: | https://doi.org/10.7554/elife.58728 https://ora.ox.ac.uk/objects/uuid:3aa0d818-4962-43dc-8808-846ddb7dbce0 |
| Rights: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Αριθμός Καταχώρησης: | edsbas.485A1F4 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.7554/elife.58728 |
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