Academic Journal
Glymphatic clearance as revealed by diffusion tensor imaging along the perivascular space (DTI-ALPS) is associated with Alzheimer's disease neuropathology and periodic rsEEG alpha rhythms in mild cognitive impairment participants
| Title: | Glymphatic clearance as revealed by diffusion tensor imaging along the perivascular space (DTI-ALPS) is associated with Alzheimer's disease neuropathology and periodic rsEEG alpha rhythms in mild cognitive impairment participants |
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| Authors: | Lopez S., Del Percio C., Lizio R., Noce G., Carpi M., Arnaldi D., Fama F., Pardini M., Massa F., Marinozzi F., Bini F., Treves G., Soricelli A., Salvatore M., Giubilei F., Ziccardi L., Guntekin B., Yener G., Ferri R., Lanuzza B., Stocchi F., Vacca L., Coletti C., Infarinato F., Romano P., Marizzoni M., Frisoni G. B., Barone P., Cappiello A., Cuoco S., Bonanni L., D'Anselmo A., Antonini A., Fiorenzato E., Cauzzo S., Biundo R., D'Antonio F., De Pandis M. F., Marziali S., Bruno G., Carducci F., Babiloni C. |
| Contributors: | Lopez, S., Del Percio, C., Lizio, R., Noce, G., Carpi, M., Arnaldi, D., Fama, F., Pardini, M., Massa, F., Marinozzi, F., Bini, F., Treves, G., Soricelli, A., Salvatore, M., Giubilei, F., Ziccardi, L., Guntekin, B., Yener, G., Ferri, R., Lanuzza, B., Stocchi, F., Vacca, L., Coletti, C., Infarinato, F., Romano, P., Marizzoni, M., Frisoni, G. B., Barone, P., Cappiello, A., Cuoco, S., Bonanni, L., D'Anselmo, A., Antonini, A., Fiorenzato, E., Cauzzo, S., Biundo, R., D'Antonio, F., De Pandis, M. F., Marziali, S., Bruno, G., Carducci, F., Babiloni, C. |
| Publisher Information: | John Wiley and Sons Inc |
| Publication Year: | 2026 |
| Collection: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: | Alzheimer's disease, diffusion tensor imaging along the perivascular space, mild cognitive impairment, periodic and aperiodic components of resting state encephalogram power spectral density, resting-state electroencephalographic rhythm, spectral parametrization |
| Description: | INTRODUCTION: We evaluated whether the brain glymphatic drainage function estimated by the diffusion tensor imaging along the perivascular space (DTI-ALPS) index relates to white matter (WM) integrity, Alzheimer's disease (AD) neuropathology, resting-state electroencephalogram (rsEEG) alpha rhythms underpinning quiet vigilance, and cognitive decline in mild cognitive impairment (MCI). METHODS: Clinical, neuroimaging, and rsEEG data were analyzed in matched mild cognitive impairment due to AD (ADMCI) and MCI not due to AD (noADMCI) participants. DTI-ALPS index and aperiodic and periodic components of the rsEEG power spectra were calculated following standard pipelines. RESULTS: Lower DTI-ALPS index was associated with higher AD neuropathology and WM lesions, lower periodic rsEEG alpha rhythms, and worse cognition in patients with ADMCI and noADMCI as a whole population, with the ADMCI (over noADMCI) group showing lower DTI-ALPS index, greater AD neuropathology, and lower periodic rsEEG alpha rhythms. CONCLUSIONS: The DTI-ALPS index may capture glymphatic system impairment linked to AD neuropathology, vigilance dysfunction, and cognitive decline in MCI. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/42291616; info:eu-repo/semantics/altIdentifier/wos/WOS:001790642500001; volume:18; issue:2; firstpage:e70384; lastpage:e70384; journal:ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING; https://hdl.handle.net/11577/3600898 |
| DOI: | 10.1002/dad2.70384 |
| Availability: | https://hdl.handle.net/11577/3600898 https://doi.org/10.1002/dad2.70384 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.4403861 |
| Database: | BASE |
| DOI: | 10.1002/dad2.70384 |
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