Academic Journal
Glymphatic clearance as revealed by diffusion tensor imaging along the perivascular space (DTI-ALPS) is associated with Alzheimer's disease neuropathology and periodic rsEEG alpha rhythms in mild cognitive impairment participants
| Τίτλος: | Glymphatic clearance as revealed by diffusion tensor imaging along the perivascular space (DTI-ALPS) is associated with Alzheimer's disease neuropathology and periodic rsEEG alpha rhythms in mild cognitive impairment participants |
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| Συγγραφείς: | Lopez S., Del Percio C., Lizio R., Noce G., Carpi M., Arnaldi D., Fama F., Pardini M., Massa F., Marinozzi F., Bini F., Treves G., Soricelli A., Salvatore M., Giubilei F., Ziccardi L., Guntekin B., Yener G., Ferri R., Lanuzza B., Stocchi F., Vacca L., Coletti C., Infarinato F., Romano P., Marizzoni M., Frisoni G. B., Barone P., Cappiello A., Cuoco S., Bonanni L., D'Anselmo A., Antonini A., Fiorenzato E., Cauzzo S., Biundo R., D'Antonio F., De Pandis M. F., Marziali S., Bruno G., Carducci F., Babiloni C. |
| Συνεισφορές: | Lopez, S., Del Percio, C., Lizio, R., Noce, G., Carpi, M., Arnaldi, D., Fama, F., Pardini, M., Massa, F., Marinozzi, F., Bini, F., Treves, G., Soricelli, A., Salvatore, M., Giubilei, F., Ziccardi, L., Guntekin, B., Yener, G., Ferri, R., Lanuzza, B., Stocchi, F., Vacca, L., Coletti, C., Infarinato, F., Romano, P., Marizzoni, M., Frisoni, G. B., Barone, P., Cappiello, A., Cuoco, S., Bonanni, L., D'Anselmo, A., Antonini, A., Fiorenzato, E., Cauzzo, S., Biundo, R., D'Antonio, F., De Pandis, M. F., Marziali, S., Bruno, G., Carducci, F., Babiloni, C. |
| Στοιχεία εκδότη: | John Wiley and Sons Inc |
| Έτος έκδοσης: | 2026 |
| Συλλογή: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Θεματικοί όροι: | Alzheimer's disease, diffusion tensor imaging along the perivascular space, mild cognitive impairment, periodic and aperiodic components of resting state encephalogram power spectral density, resting-state electroencephalographic rhythm, spectral parametrization |
| Περιγραφή: | INTRODUCTION: We evaluated whether the brain glymphatic drainage function estimated by the diffusion tensor imaging along the perivascular space (DTI-ALPS) index relates to white matter (WM) integrity, Alzheimer's disease (AD) neuropathology, resting-state electroencephalogram (rsEEG) alpha rhythms underpinning quiet vigilance, and cognitive decline in mild cognitive impairment (MCI). METHODS: Clinical, neuroimaging, and rsEEG data were analyzed in matched mild cognitive impairment due to AD (ADMCI) and MCI not due to AD (noADMCI) participants. DTI-ALPS index and aperiodic and periodic components of the rsEEG power spectra were calculated following standard pipelines. RESULTS: Lower DTI-ALPS index was associated with higher AD neuropathology and WM lesions, lower periodic rsEEG alpha rhythms, and worse cognition in patients with ADMCI and noADMCI as a whole population, with the ADMCI (over noADMCI) group showing lower DTI-ALPS index, greater AD neuropathology, and lower periodic rsEEG alpha rhythms. CONCLUSIONS: The DTI-ALPS index may capture glymphatic system impairment linked to AD neuropathology, vigilance dysfunction, and cognitive decline in MCI. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/42291616; info:eu-repo/semantics/altIdentifier/wos/WOS:001790642500001; volume:18; issue:2; firstpage:e70384; lastpage:e70384; journal:ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING; https://hdl.handle.net/11577/3600898 |
| DOI: | 10.1002/dad2.70384 |
| Διαθεσιμότητα: | https://hdl.handle.net/11577/3600898 https://doi.org/10.1002/dad2.70384 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.4403861 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1002/dad2.70384 |
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