Academic Journal
Device-related complications in subcutaneous versus transvenous ICD: a secondary analysis of the PRAETORIAN trial
| Τίτλος: | Device-related complications in subcutaneous versus transvenous ICD: a secondary analysis of the PRAETORIAN trial |
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| Συγγραφείς: | Knops, RE, Pepplinkhuizen, S, Delnoy, PPHM, Boersma, LVA, Kuschyk, J, El-Chami, MF, Bonnemeier, H, Behr, ER, Brouwer, TF, Kaab, S, Mittal, S, Quast, AFBE, van der Stuijt, W, Smeding, L, de Veld, JA, Tijssen, JGP, Bijsterveld, NR, Richter, S, Brouwer, MA, de Groot, JR, Kooiman, KM, Lambiase, PD, Neuzil, P, Vernooy, K, Alings, M, Betts, TR, Bracke, FALE, Burke, MC, de Jong, JSSG, Wright, DJ, Jansen, WPJ, Whinnett, ZI, Nordbeck, P, Knaut, M, Philbert, BT, van Opstal, JM, Chicos, AB, Allaart, CP, Borger van der Burg, AE, Dizon, JM, Miller, MA, Nemirovsky, D, Surber, R, Upadhyay, GA, Weiss, R, de Weger, A, Wilde, AAM, Olde Nordkamp, LRA |
| Στοιχεία εκδότη: | Oxford University Press |
| Έτος έκδοσης: | 2022 |
| Συλλογή: | St George's University of London: Repository |
| Περιγραφή: | BACKGROUND: The subcutaneous ICD (S-ICD) is developed to overcome lead-related complications and systemic infections, inherent to transvenous ICD (TV-ICD) therapy. The PRAETORIAN trial demonstrated that the S-ICD is non-inferior to the TV-ICD with regard to the combined primary endpoint of inappropriate shocks and complications. This prespecified secondary analysis evaluates all complications in the PRAETORIAN trial. METHODS: The PRAETORIAN trial is an international, multicenter, randomised trial in which 849 patients with an indication for ICD therapy were randomised to receive an SICD (N = 426) or TV-ICD (N = 423) and followed for a median of 49 months. Endpoints were device-related complications, lead-related complications, systemic infections and the need for invasive interventions. RESULTS: Thirty-six device-related complications occurred in 31 patients in the S-ICD group of which bleedings were the most frequent. In the TV-ICD group 49 complications occurred in 44 patients of which lead-dysfunction was most frequent (HR 0.69; P =0.11). In both groups half of all complications were within 30 days after implantation. Lead-related complications and systemic infections occurred significantly less in the S-ICD group compared to the TV-ICD group (P <0.001, P =0.03 respectively). Significantly more complications required invasive interventions in the TV-ICD group compared to the S-ICD group (8.3% vs. 4.3%, HR 0.59; P =0.047). CONCLUSIONS: This secondary analysis shows that, lead-related complications and systemic infections are more prevalent in the TV-ICD group compared to the S-ICD group. In addition, complications in the TV-ICD group were more severe as they required significantly more invasive interventions. This data contributes to shared decision making in clinical practice. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Γλώσσα: | English |
| ISSN: | 1522-9645 |
| Relation: | https://openaccess.sgul.ac.uk/id/eprint/114849/6/ehac496.pdf; https://openaccess.sgul.ac.uk/id/eprint/114849/11/ehac496_supplementary_data.docx; https://openaccess.sgul.ac.uk/id/eprint/114849/1/ehac496.pdf; Knops, RE; Pepplinkhuizen, S; Delnoy, PPHM; Boersma, LVA; Kuschyk, J; El-Chami, MF; Bonnemeier, H; Behr, ER; Brouwer, TF; Kaab, S; et al. Knops, RE; Pepplinkhuizen, S; Delnoy, PPHM; Boersma, LVA; Kuschyk, J; El-Chami, MF; Bonnemeier, H; Behr, ER; Brouwer, TF; Kaab, S; Mittal, S; Quast, AFBE; van der Stuijt, W; Smeding, L; de Veld, JA; Tijssen, JGP; Bijsterveld, NR; Richter, S; Brouwer, MA; de Groot, JR; Kooiman, KM; Lambiase, PD; Neuzil, P; Vernooy, K; Alings, M; Betts, TR; Bracke, FALE; Burke, MC; de Jong, JSSG; Wright, DJ; Jansen, WPJ; Whinnett, ZI; Nordbeck, P; Knaut, M; Philbert, BT; van Opstal, JM; Chicos, AB; Allaart, CP; Borger van der Burg, AE; Dizon, JM; Miller, MA; Nemirovsky, D; Surber, R; Upadhyay, GA; Weiss, R; de Weger, A; Wilde, AAM; Olde Nordkamp, LRA (2022) Device-related complications in subcutaneous versus transvenous ICD: a secondary analysis of the PRAETORIAN trial. Eur Heart J, 43 (47). pp. 4872-4883. ISSN 1522-9645 https://doi.org/10.1093/eurheartj/ehac496 SGUL Authors: Behr, Elijah Raphael |
| DOI: | 10.1093/eurheartj/ehac496 |
| Διαθεσιμότητα: | https://openaccess.sgul.ac.uk/id/eprint/114849/ https://openaccess.sgul.ac.uk/id/eprint/114849/6/ehac496.pdf https://openaccess.sgul.ac.uk/id/eprint/114849/11/ehac496_supplementary_data.docx https://openaccess.sgul.ac.uk/id/eprint/114849/1/ehac496.pdf https://doi.org/10.1093/eurheartj/ehac496 |
| Rights: | cc_by_nc_4 |
| Αριθμός Καταχώρησης: | edsbas.41E5922C |
| Βάση Δεδομένων: | BASE |
| ISSN: | 15229645 |
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| DOI: | 10.1093/eurheartj/ehac496 |