Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
The trans-ancestral genomic architecture of glycemic traits |
| Συγγραφείς: |
Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Magi, R., Waage, J., Li-Gao, R., Chan, K. H., Yao, J., Anasanti, M. D., Chu, A. Y., Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J.-J., Huo, S., Kaakinen, M. A., Louie, T., Maerz, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C., Nolte, I. M., North, K. E., Raulerson, C. K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Southam, L., Stewart, I. D., Wang, C. A., Wang, Y., Wu, P., Zhang, W., Ahluwalia, T. S., Appel, E. V., Bielak, L. F., Brody, J. A., Burtt, N. P., Cabrera, C. P., Cade, B. E. |
| Στοιχεία εκδότη: |
Springer Nature |
| Έτος έκδοσης: |
2021 |
| Θεματικοί όροι: |
envir, psy |
| Περιγραφή: |
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. |
| Τύπος εγγράφου: |
article in journal/newspaper |
| Γλώσσα: |
English |
| Relation: |
http://urn.fi/urn:nbn:fi-fe2022030422054 |
| Διαθεσιμότητα: |
http://urn.fi/urn:nbn:fi-fe2022030422054 |
| Rights: |
undefined |
| Αριθμός Καταχώρησης: |
edsbas.40C2767D |
| Βάση Δεδομένων: |
BASE |