Academic Journal
Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso.
| Τίτλος: | Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso. |
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| Συγγραφείς: | Markianos, Kyriacos, Bischoff, Emmanuel, Mitri, Christian, Guelbéogo, Wamdaogo, Gneme, Awa, Eiglmeier, Karin, Holm, Inge, Sagnon, N’fale, Vernick, Kenneth D, Riehle, Michelle |
| Συνεισφορές: | Harvard Medical School Boston (HMS), Génétique et Génomique des Insectes vecteurs, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Centre National de Recherche et de Formation sur le Paludisme Ouagadougou, Burkina Faso (CNRFP), University of Minnesota Twin Cities (UMN), University of Minnesota System (UMN), This work received financial support to KDV from the European Commission (http://ec.europa.eu/research/fp7/index_en.cfm), FP7 Infrastructures #228421 Infravec, European Research Council (http://erc.europa.eu/funding-and-grants), Support for frontier research, Advanced Grant #323173, National Institutes of Health (http://grants.nih.gov/grants/guid/index.html?CFID=49130899&CFTOKEN=42657567&jsessionid=f630163215e4bea230912b25e13534c77157), NIAIDR01 #AI073685, and French Laboratoire d'Excellence (http://www.enseignementsup-recherche.gouv.fr/cid55551/investissementsavenir-projets-labex-par-region-domaine.html), "Integrative Biology of Emerging Infectious Diseases" #ANR-10-LABX-62-IBEID., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 228421,FP7-INFRASTRUCTURES-2008-1,FP7-INFRASTRUCTURES-2008-1,INFRAVEC(2009), European Project: 323173,ERC-2012-ADG_20120314,ERC-2012-ADG_20120314,AnoPath(2013) |
| Πηγή: | ISSN: 1932-6203. |
| Στοιχεία εκδότη: | CCSD Public Library of Science |
| Έτος έκδοσης: | 2016 |
| Συλλογή: | Institut Pasteur: HAL |
| Θεματικοί όροι: | MESH: Animals, MESH: Anopheles/classification, MESH: Population Dynamics, MESH: Species Specificity, MESH: Anopheles/genetics, MESH: Burkina Faso/epidemiology, MESH: Genetic Structures, MESH: Genetics, Population/methods, MESH: Genome, Insect/genetics, MESH: Genotype, MESH: Geography, MESH: Humans, MESH: Insect Vectors/classification, MESH: Insect Vectors/genetics, MESH: Linkage Disequilibrium, MESH: Malaria, Falciparum/epidemiology, Falciparum/parasitology, MESH: Phylogeny, MESH: Polymorphism, Single Nucleotide, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology |
| Περιγραφή: | International audience ; Members of the Anopheles gambiae species complex are primary vectors of human malaria in Africa. Population heterogeneities for ecological and behavioral attributes expand and stabilize malaria transmission over space and time, and populations may change in response to vector control, urbanization and other factors. There is a need for approaches to comprehensively describe the structure and characteristics of a sympatric local mosquito population, because incomplete knowledge of vector population composition may hinder control efforts. To this end, we used a genome-wide custom SNP typing array to analyze a population collection from a single geographic region in West Africa. The combination of sample depth (n = 456) and marker density (n = 1536) unambiguously resolved population subgroups, which were also compared for their relative susceptibility to natural genotypes of Plasmodium falciparum malaria. The population subgroups display fluctuating patterns of differentiation or sharing across the genome. Analysis of linkage disequilibrium identified 19 new candidate genes for association with underlying population divergence between sister taxa, A. coluzzii (M-form) and A. gambiae (S-form). |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/26731649; info:eu-repo/grantAgreement//228421/EU/Research capacity for the implementation of genetic control of mosquitoes/INFRAVEC; info:eu-repo/grantAgreement//323173/EU/Genetics of mosquito resistance to pathogens/AnoPath; PUBMED: 26731649 |
| DOI: | 10.1371/journal.pone.0145308 |
| Διαθεσιμότητα: | https://pasteur.hal.science/pasteur-02008317 https://pasteur.hal.science/pasteur-02008317v1/document https://pasteur.hal.science/pasteur-02008317v1/file/journal.pone.0145308.PDF https://doi.org/10.1371/journal.pone.0145308 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Αριθμός Καταχώρησης: | edsbas.38DB8833 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1371/journal.pone.0145308 |
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