Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Newborn body composition and child cardiovascular risk markers: a prospective multi-ethnic Asian cohort study |
| Συγγραφείς: |
Ong, YY, Tint, MT, Aris, IM, Yuan, WL, Chen, LW, Fortier, MV, Choo, J, Ling, LH, Shek, L, Tan, KH, Gluckman, PD, Yap, F, Chong, YS, Godfrey, KM, Chong, MFF, Chan, SY, Eriksson, JG, Wlodek, ME, De Lucia Rolfe, E, Ong, KK, Michael, N, Lee, YS |
| Στοιχεία εκδότη: |
OXFORD UNIV PRESS |
| Έτος έκδοσης: |
2022 |
| Συλλογή: |
The University of Melbourne: Digital Repository |
| Περιγραφή: |
BACKGROUND: Early epidemiological studies have associated low birthweight with increased cardiovascular risk. We aimed to examine whether the fat and fat-free components of birthweight have differing relationships with childhood cardiovascular risk markers. METHODS: In the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort, air displacement plethysmography was conducted within 24 h after delivery in 290 naturally conceived singletons. We investigated associations of newborn cohort-specific standardized z-score of fat mass, fat-free mass, body fat percentage and birthweight on child (at 6 years of age) carotid intima-media thickness, pulse wave velocity, blood pressure, prehypertension/hypertension (>110/70 mmHg) and standardized systolic and diastolic blood pressure (SBP and DBP) trajectories (at 3-6 years of age), taking account of maternal education, height, tobacco exposure, parity, ethnicity, child's sex, gestational age, age at follow-up, and other maternal factors. RESULTS: Clear inverse associations were seen for blood pressure with z-score of fat mass [SBP, β (95% CI): -1.31 mmHg (-2.57, -0.06); DBP: -0.79 mmHg (-1.74, 0.15)] and body fat percentage [SBP: -1.46 mmHg (-2.73, -0.19); DBP: -0.80 mmHg (-1.75, 0.16)], but not with fat-free mass [SBP: 0.27 mmHg (-1.29, 1.83)]; DBP: -0.14 mmHg (-1.30, 1.03)]. Being in the lowest tertile of fat mass or body fat percentage was associated with higher blood pressure trajectories and prehypertension/hypertension risk [OR (95% CI), fat mass: 4.23 (1.41, 12.68); body fat percentage: 3.22 (1.09, 9.53)] without concomitantly higher overweight/obesity risk. CONCLUSIONS: At birth, low adiposity was associated with increased childhood blood pressure. Low newborn adiposity might serve as a marker of poor fetal growth or suboptimal intrauterine conditions associated with hypertension risk later in life. |
| Τύπος εγγράφου: |
article in journal/newspaper |
| Γλώσσα: |
English |
| ISSN: |
0300-5771 |
| Relation: |
pii: 6652263; https://hdl.handle.net/11343/335802 |
| Διαθεσιμότητα: |
https://hdl.handle.net/11343/335802 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Αριθμός Καταχώρησης: |
edsbas.355F6E9A |
| Βάση Δεδομένων: |
BASE |