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Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study

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Τίτλος: Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study
Συγγραφείς: Ismini Grapsa, Eirini Mamalaki, Eva Ntanasi, Mary H. Kosmidis, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas, Mary Yannakoulia
Πηγή: Nutrients, Vol 15, Iss 7, p 1795 (2023)
Στοιχεία εκδότη: MDPI AG
Έτος έκδοσης: 2023
Συλλογή: Directory of Open Access Journals: DOAJ Articles
Θεματικοί όροι: obesity, weight loss, body mass index, cognitive functioning, cognitive decline, older adults, Nutrition. Foods and food supply, TX341-641
Περιγραφή: Given the increase in the aging population and thus in the prevalence of dementia, the identification of protective factors against cognitive decline is necessary. In a cohort of 1076 non-demented adults ≥ 65 years old (59.7% women) from the HELIAD study, we assessed whether changes in body mass index (BMI) were associated with changes in cognition over a 3-year follow-up period separately for those ≤ 75 and >75 years old. We identified six BMI trajectory groups based on participants’ BMI status at baseline and at the first follow-up visit; normal to normal BMI was the reference group. Major cognitive domains were evaluated, and a composite index reflecting global cognition was calculated. In participants aged ≤75 years, weight loss—moving from obesity to overweight or normal BMI—was associated with less decline in the memory composite score over time (β = 0.141; p = 0.035), while 3-year maintenance of a BMI ≥ 25 kg/m 2 was related to greater reduction in the visuospatial composite score over time (β = −0.093; p = 0.020). Regarding participants aged >75 years, 3-year maintenance of a BMI ≥ 30 kg/m 2 contributed to a slower rate of decline in the memory composite score over time (β = 0.102; p = 0.042), whereas weight loss—from overweight to normal BMI—was associated with a decreased attention/processing speed composite score longitudinally (β = −0.275; p = 0.043). Our findings indicated that the association between changes in BMI and cognitive functioning was modified by age. Weight management may have the potential to delay cognitive decline in older adults.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: https://www.mdpi.com/2072-6643/15/7/1795; https://doaj.org/toc/2072-6643; https://doaj.org/article/64c81610d07640b88cf31b281b41a449
DOI: 10.3390/nu15071795
Διαθεσιμότητα: https://doi.org/10.3390/nu15071795
https://doaj.org/article/64c81610d07640b88cf31b281b41a449
Αριθμός Καταχώρησης: edsbas.2BA56087
Βάση Δεδομένων: BASE
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  – Url: https://doi.org/10.3390/nu15071795#
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  Data: Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study
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  Data: <searchLink fieldCode="AR" term="%22Ismini+Grapsa%22">Ismini Grapsa</searchLink><br /><searchLink fieldCode="AR" term="%22Eirini+Mamalaki%22">Eirini Mamalaki</searchLink><br /><searchLink fieldCode="AR" term="%22Eva+Ntanasi%22">Eva Ntanasi</searchLink><br /><searchLink fieldCode="AR" term="%22Mary+H%2E+Kosmidis%22">Mary H. Kosmidis</searchLink><br /><searchLink fieldCode="AR" term="%22Efthimios+Dardiotis%22">Efthimios Dardiotis</searchLink><br /><searchLink fieldCode="AR" term="%22Georgios+M%2E+Hadjigeorgiou%22">Georgios M. Hadjigeorgiou</searchLink><br /><searchLink fieldCode="AR" term="%22Paraskevi+Sakka%22">Paraskevi Sakka</searchLink><br /><searchLink fieldCode="AR" term="%22Nikolaos+Scarmeas%22">Nikolaos Scarmeas</searchLink><br /><searchLink fieldCode="AR" term="%22Mary+Yannakoulia%22">Mary Yannakoulia</searchLink>
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  Data: Nutrients, Vol 15, Iss 7, p 1795 (2023)
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  Data: MDPI AG
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  Data: 2023
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  Data: Given the increase in the aging population and thus in the prevalence of dementia, the identification of protective factors against cognitive decline is necessary. In a cohort of 1076 non-demented adults ≥ 65 years old (59.7% women) from the HELIAD study, we assessed whether changes in body mass index (BMI) were associated with changes in cognition over a 3-year follow-up period separately for those ≤ 75 and >75 years old. We identified six BMI trajectory groups based on participants’ BMI status at baseline and at the first follow-up visit; normal to normal BMI was the reference group. Major cognitive domains were evaluated, and a composite index reflecting global cognition was calculated. In participants aged ≤75 years, weight loss—moving from obesity to overweight or normal BMI—was associated with less decline in the memory composite score over time (β = 0.141; p = 0.035), while 3-year maintenance of a BMI ≥ 25 kg/m 2 was related to greater reduction in the visuospatial composite score over time (β = −0.093; p = 0.020). Regarding participants aged >75 years, 3-year maintenance of a BMI ≥ 30 kg/m 2 contributed to a slower rate of decline in the memory composite score over time (β = 0.102; p = 0.042), whereas weight loss—from overweight to normal BMI—was associated with a decreased attention/processing speed composite score longitudinally (β = −0.275; p = 0.043). Our findings indicated that the association between changes in BMI and cognitive functioning was modified by age. Weight management may have the potential to delay cognitive decline in older adults.
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  Data: https://www.mdpi.com/2072-6643/15/7/1795; https://doaj.org/toc/2072-6643; https://doaj.org/article/64c81610d07640b88cf31b281b41a449
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      – SubjectFull: weight loss
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            – TitleFull: Nutrients, Vol 15, Iss 7, p 1795 (2023
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