Academic Journal
Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study
| Τίτλος: | Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study |
|---|---|
| Συγγραφείς: | Ismini Grapsa, Eirini Mamalaki, Eva Ntanasi, Mary H. Kosmidis, Efthimios Dardiotis, Georgios M. Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas, Mary Yannakoulia |
| Πηγή: | Nutrients, Vol 15, Iss 7, p 1795 (2023) |
| Στοιχεία εκδότη: | MDPI AG |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | Directory of Open Access Journals: DOAJ Articles |
| Θεματικοί όροι: | obesity, weight loss, body mass index, cognitive functioning, cognitive decline, older adults, Nutrition. Foods and food supply, TX341-641 |
| Περιγραφή: | Given the increase in the aging population and thus in the prevalence of dementia, the identification of protective factors against cognitive decline is necessary. In a cohort of 1076 non-demented adults ≥ 65 years old (59.7% women) from the HELIAD study, we assessed whether changes in body mass index (BMI) were associated with changes in cognition over a 3-year follow-up period separately for those ≤ 75 and >75 years old. We identified six BMI trajectory groups based on participants’ BMI status at baseline and at the first follow-up visit; normal to normal BMI was the reference group. Major cognitive domains were evaluated, and a composite index reflecting global cognition was calculated. In participants aged ≤75 years, weight loss—moving from obesity to overweight or normal BMI—was associated with less decline in the memory composite score over time (β = 0.141; p = 0.035), while 3-year maintenance of a BMI ≥ 25 kg/m 2 was related to greater reduction in the visuospatial composite score over time (β = −0.093; p = 0.020). Regarding participants aged >75 years, 3-year maintenance of a BMI ≥ 30 kg/m 2 contributed to a slower rate of decline in the memory composite score over time (β = 0.102; p = 0.042), whereas weight loss—from overweight to normal BMI—was associated with a decreased attention/processing speed composite score longitudinally (β = −0.275; p = 0.043). Our findings indicated that the association between changes in BMI and cognitive functioning was modified by age. Weight management may have the potential to delay cognitive decline in older adults. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | https://www.mdpi.com/2072-6643/15/7/1795; https://doaj.org/toc/2072-6643; https://doaj.org/article/64c81610d07640b88cf31b281b41a449 |
| DOI: | 10.3390/nu15071795 |
| Διαθεσιμότητα: | https://doi.org/10.3390/nu15071795 https://doaj.org/article/64c81610d07640b88cf31b281b41a449 |
| Αριθμός Καταχώρησης: | edsbas.2BA56087 |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.3390/nu15071795 |
|---|