Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Microaxial Left Ventricular Assist Device in Cardiogenic Shock: A Systematic Review and Meta-Analysis |
| Συγγραφείς: |
Tan, SR, Low, CJW, Ng, WL, Ling, RR, Tan, CS, Lim, SL, Cherian, R, Lin, W, Shekar, K, Mitra, S, MacLaren, G, Ramanathan, K |
| Στοιχεία εκδότη: |
MDPI AG |
| Έτος έκδοσης: |
2022 |
| Συλλογή: |
The University of Melbourne: Digital Repository |
| Περιγραφή: |
Microaxial left ventricular assist devices (LVAD) are increasingly used to support patients with cardiogenic shock; however, outcome results are limited to single-center studies, registry data and select reviews. We conducted a systematic review and meta-analysis, searching three databases for relevant studies reporting on microaxial LVAD use in adults with cardiogenic shock. We conducted a random-effects meta-analysis (DerSimonian and Laird) based on short-term mortality (primary outcome), long-term mortality and device complications (secondary outcomes). We assessed the risk of bias and certainty of evidence using the Joanna Briggs Institute and the GRADE approaches, respectively. A total of 63 observational studies (3896 patients), 6 propensity-score matched (PSM) studies and 2 randomized controlled trials (RCTs) were included (384 patients). The pooled short-term mortality from observational studies was 46.5% (95%-CI: 42.7-50.3%); this was 48.9% (95%-CI: 43.8-54.1%) amongst PSM studies and RCTs. The pooled mortality at 90 days, 6 months and 1 year was 41.8%, 51.1% and 54.3%, respectively. Hemolysis and access-site bleeding were the most common complications, each with a pooled incidence of around 20%. The reported mortality rate of microaxial LVADs was not significantly lower than extracorporeal membrane oxygenation (ECMO) or intra-aortic balloon pumps (IABP). Current evidence does not suggest any mortality benefit when compared to ECMO or IABP. |
| Τύπος εγγράφου: |
article in journal/newspaper |
| Γλώσσα: |
English |
| ISSN: |
2075-1729 |
| Relation: |
pii: life12101629; https://hdl.handle.net/11343/335216 |
| Διαθεσιμότητα: |
https://hdl.handle.net/11343/335216 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Αριθμός Καταχώρησης: |
edsbas.26BE1E14 |
| Βάση Δεδομένων: |
BASE |