Academic Journal
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
| Τίτλος: | Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth |
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| Συγγραφείς: | Beaumont, Robin N., Flatley, Christopher, Vaudel, Marc, Wu, Xiaoping, Chen, Jing, Moen, Gunn Helen, Skotte, Line, Helgeland, Øyvind, Solé-Navais, Pol, Banasik, Karina, Albiñana, Clara, Ronkainen, Justiina, Fadista, João, Stinson, Sara Elizabeth, Trajanoska, Katerina, Wang, Carol A., Westergaard, David, Srinivasan, Sundararajan, Sánchez-Soriano, Carlos, Bilbao, Jose Ramon, Allard, Catherine, Groleau, Marika, Kuulasmaa, Teemu, Leirer, Daniel J., White, Frédérique, Jacques, Pierre Étienne, Cheng, Haoxiang, Hao, Ke, Andreassen, Ole A., Åsvold, Bjørn Olav, Atalay, Mustafa, Bhatta, Laxmi, Bouchard, Luigi, Brumpton, Ben Michael, Brunak, Søren, Bybjerg-Grauholm, Jonas, Ebbing, Cathrine, Elliott, Paul, Engelbrechtsen, Line, Erikstrup, Christian, Estarlich, Marisa, Franks, Stephen, Gaillard, Romy, Geller, Frank, Grove, Jakob, Hougaard, David M., Kajantie, Eero, Morgen, Camilla S., Nohr, Ellen A., Nyegaard, Mette, Palmer, Colin N.A., Pedersen, Ole Birger, Rivadeneira, Fernando, Sebert, Sylvain, Shields, Beverley M., Stoltenberg, Camilla, Surakka, Ida, Thørner, Lise Wegner, Ullum, Henrik, Vaarasmaki, Marja, Vilhjalmsson, Bjarni J., Willer, Cristen J., Lakka, Timo A., Gybel-Brask, Dorte, Bustamante, Mariona, Hansen, Torben, Pearson, Ewan R., Reynolds, Rebecca M., Ostrowski, Sisse R., Pennell, Craig E., Jaddoe, Vincent W.V., Felix, Janine F., Hattersley, Andrew T., Melbye, Mads, Lawlor, Deborah A., Hveem, Kristian, Werge, Thomas, Nielsen, Henriette Svarre, Magnus, Per, Evans, David M., Jacobsson, Bo, Järvelin, Marjo Riitta, Zhang, Ge, Hivert, Marie France, Johansson, Stefan, Freathy, Rachel M., Feenstra, Bjarke, Njølstad, Pål R. |
| Συνεισφορές: | Institute for Molecular Medicine Finland, HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital, Clinicum |
| Στοιχεία εκδότη: | Nature Research |
| Έτος έκδοσης: | 2024 |
| Συλλογή: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| Θεματικοί όροι: | Genetics, developmental biology, physiology |
| Περιγραφή: | A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth. ; Peer reviewed |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISBN: | 978-0-01-079854-8 0-01-079854-4 |
| Relation: | We are grateful to M. Efremova and S.A. Teichmann (Wellcome Sanger Institute, Cambridge, UK) who shared the maternal–fetal interface single-cell RNA data. Full acknowledgements and details of supporting grants are found in the Supplementary Information.; https://hdl.handle.net/10138/572424; 85173791824; 001079854400001 |
| Διαθεσιμότητα: | https://hdl.handle.net/10138/572424 |
| Rights: | cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| Αριθμός Καταχώρησης: | edsbas.105E26C2 |
| Βάση Δεδομένων: | BASE |
| ISBN: | 9780010798548 0010798544 |
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