Academic Journal
[The hemodiafiltration with infusion of acetate-free dialysis fluid can modify the inflammatory response in patients 'high responders' to inflammatory stimuli?]
| Title: | [The hemodiafiltration with infusion of acetate-free dialysis fluid can modify the inflammatory response in patients 'high responders' to inflammatory stimuli?] |
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| Authors: | SAVOLDI S., SERENI L., BERTOK S., IANCHE M., BIANCO F., MAREGA A., VIANELLO S., ZANCHI R., KLEIN P., CICINATO P., PACOR G., GENNARI M., BOSUTTI, ALESSANDRA, BIOLO, GIANNI, AMOROSO A., PANZETTA G. |
| Contributors: | Savoldi, S., Sereni, L., Bertok, S., Ianche, M., Bianco, F., Marega, A., Vianello, S., Zanchi, R., Klein, P., Cicinato, P., Pacor, G., Gennari, M., Bosutti, Alessandra, Biolo, Gianni, Amoroso, A., Panzetta, G. |
| Source: | Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. 21 |
| Publisher Information: | 2004. |
| Publication Year: | 2004 |
| Subject Terms: | Inflammation, Male, Cross-Over Studies, Acetate-free dialysis fluid, inflammatory response, Hemodiafiltration, Acetates, Hemodialysis Solutions, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Humans, Female, hemodiafiltration, inflammation, C-reactive protein, genetic polymorphisms, interleukin-10, Aged |
| Description: | This study aimed to verify the effects of paired hemodiafiltration on-line (PHF-AF) on inflammation in patients who were "high responders" to inflammatory stimuli: elevated C-reactive protein (CRP), genetic polymorphisms influencing a low transcription for interleukin-10 (IL-10) and a high transcription for IFN-gamma.Ten patients selected as high responders for IFN-gamma and low responders for IL-10 were included in a crossover study to compare PHF-AF and standard bicarbonate hemodialysis (BHD). At study entry and before the start of each dialysis session the following examinations were performed: CRP, albumin, fibrinogen, ferritin, transferrin, prealbumin and serum levels of IL-6, IL-10, IFN-gamma, tumor necrosis factor-alpha (TNF-alpha). After the 1st and 3rd week of the study, the blood samples were also collected after the dialysis session.. There was a significant reduction in albumin and prealbumin in PHF-AF patients during the study; none of the other parameters were changed in both patient groups. CRP tended to be elevated after dialysis in both PHF-AF and BHD. While IL-6, IL-10 and IFN-gamma were unchanged during the dialysis session, there was a significant variation in TNF-alpha levels, which were increased in BHD (from 10.9 +/- 3.1 to 14.7 +/- 4.1 pg/mL; p=0.004) and reduced in PHF-AF (from 11.9 +/-2.8 to 6.3 +/- 2.2 pg/mL; p=0.0004).Although the cytokine levels were unchanged during the study in both BHD and PHF-AF, the modification of TNF-alpha during the dialysis session was considered as inflammatory significance. |
| Document Type: | Article |
| Language: | Italian |
| ISSN: | 0393-5590 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/15747295 http://hdl.handle.net/11368/1706807 https://hdl.handle.net/11368/1706807 https://hdl.handle.net/2318/30911 |
| Accession Number: | edsair.pmid.dedup....f80a7da8e5e44e7e1cbb13ca17e7ef5b |
| Database: | OpenAIRE |
| ISSN: | 03935590 |
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