Academic Journal
Macrophage and tumor cell responses to repetitive pulsed X-ray radiation
| Title: | Macrophage and tumor cell responses to repetitive pulsed X-ray radiation |
|---|---|
| Authors: | Tretyakova, M. S., Ryabov, V. B., Klimov, I. A., Kutenkov, O. P., Kzhyshkowska, Julia G., Bolshakov, Mikhail A., Rostov, Vladislav V., Cherdyntseva, Nadezhda V., Buldakov, Mikhail A. |
| Source: | Journal of Physics: Conference Series. 2017. Vol. 830. P. 012045 (1-6) |
| Publisher Information: | IOP Publishing, 2017. |
| Publication Year: | 2017 |
| Subject Terms: | макрофаги, 0301 basic medicine, опухолевые клетки, 03 medical and health sciences, 0302 clinical medicine, импульсное рентгеновское излучение, 3. Good health |
| Description: | To study a response of tumor cells and macrophages to the repetitive pulsed low-dose X-ray radiation. Methods. Tumor growth and lung metastasis of mice with an injected Lewis lung carcinoma were analysed, using C57Bl6. Monocytes were isolated from a human blood, using CD14+ magnetic beads. IL6, IL1-betta, and TNF-alpha were determined by ELISA. For macrophage phenotyping, a confocal microscopy was applied. "Sinus-150" was used for the generation of pulsed X-ray radiation (the absorbed dose was below 0.1 Gy, the pulse repetition frequency was 10 pulse/sec). The irradiation of mice by 0.1 Gy pulsed X-rays significantly inhibited the growth of primary tumor and reduced the number of metastatic colonies in the lung. Furthermore, the changes in macrophage phenotype and cytokine secretion were observed after repetitive pulsed X-ray radiation. Conclusion. Macrophages and tumor cells had a different response to a low-dose pulsed X-ray radiation. An activation of the immune system through changes of a macrophage phenotype can result in a significant antitumor effect of the low-dose repetitive pulsed X-ray radiation. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| ISSN: | 1742-6596 1742-6588 |
| DOI: | 10.1088/1742-6596/830/1/012045 |
| Access URL: | https://inis.iaea.org/Search/search.aspx?orig_q=RN:49019619 http://ui.adsabs.harvard.edu/abs/2017JPhCS.830a2045B/abstract http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000615946 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....ff2aab5b4d2b29e3d9da5251b56e8a6f |
| Database: | OpenAIRE |
| ISSN: | 17426596 17426588 |
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| DOI: | 10.1088/1742-6596/830/1/012045 |