Academic Journal
Neurodevelopmental predictors of treatment response in schizophrenia and bipolar disorder
| Title: | Neurodevelopmental predictors of treatment response in schizophrenia and bipolar disorder |
|---|---|
| Authors: | Iftimovici, Anton, Krebs, Emma, Dalfin, William, Legrand, Adrien, Scoriels, Linda, Martinez, Gilles, Bendjemaa, Narjès, Duchesnay, Edouard, Chaumette, Boris, Krebs, Marie-Odile |
| Contributors: | Duchesnay, Edouard |
| Source: | Psychol Med |
| Publication Status: | Preprint |
| Publisher Information: | Cambridge University Press (CUP), 2024. |
| Publication Year: | 2024 |
| Subject Terms: | schizophrenia, bipolar disorder, neurological soft signs, neurodevelopment, treatment response, Original Article, [MATH] Mathematics [math], age at onset of disease, [INFO] Computer Science [cs], [STAT] Statistics [stat] |
| Description: | BackgroundTreatment resistance is a major challenge in psychiatric disorders. Early detection of potential future resistance would improve prognosis by reducing the delay to appropriate treatment adjustment and recovery. Here, we sought to determine whether neurodevelopmental markers can predict therapeutic response.MethodsHealthy controls (N = 236), patients with schizophrenia (N = 280) or bipolar disorder (N = 78) with a known therapeutic outcome, were retrospectively included. Age, sex, education, early developmental abnormalities (obstetric complications, height, weight, and head circumference at birth, hyperactivity, dyslexia, epilepsy, enuresis, encopresis), neurological soft signs (NSS), and ages at first subjective impairment, clinical symptoms, treatment, and hospitalization, were recorded. A supervised algorithm leveraged NSS and age at first clinical signs to classify between resistance and response in schizophrenia.ResultsDevelopmental abnormalities were more frequent in schizophrenia and bipolar disorder than in controls. NSS significantly differed between controls, responsive, and resistant participants with schizophrenia (5.5 ± 3.0, 7.0 ± 4.0, 15.0 ± 6.0 respectively, p = 3 × 10−10) and bipolar disorder (5.5 ± 3.0, 8.3 ± 3.0, 12.5 ± 6.0 respectively, p < 1 × 10−10). In schizophrenia, but not in bipolar disorder, age at first subjective impairment was three years lower, and age at first clinical signs two years lower, in resistant than responsive subjects (p = 2 × 10−4 and p = 9 × 10−3, respectively). Age at first clinical signs and NSS accurately predicted treatment response in schizophrenia (area-under-curve: 77 ± 8%, p = 1 × 10−14).ConclusionsNeurodevelopmental features such as NSS and age of clinical onset provide a means to identify patients who may require rapid treatment adaptation. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291724001776 |
| DOI: | 10.13140/rg.2.2.36716.99203 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/39402801 https://hal.science/hal-04995685v1/document https://hal.science/hal-04995685v1 https://doi.org/10.1017/s0033291724001776 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
| Accession Number: | edsair.doi.dedup.....e8b35d0418f9345a5f00499273fff04b |
| Database: | OpenAIRE |
| ISSN: | 14698978 00332917 |
|---|---|
| DOI: | 10.1017/s0033291724001776 |