Academic Journal
Behavioural interventions to increase uptake of FIT colorectal screening in Scotland (TEMPO): a nationwide, eight-arm, factorial, randomised controlled trial
| Τίτλος: | Behavioural interventions to increase uptake of FIT colorectal screening in Scotland (TEMPO): a nationwide, eight-arm, factorial, randomised controlled trial |
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| Συγγραφείς: | Robb, Kathryn A, Young, Ben, Murphy, Marie K, Duklas, Patrycja, McConnachie, Alex, Hollands, Gareth J, McCowan, Colin, Macdonald, Sara, O'Carroll, Ronan E, O'Connor, Rory C, Steele, Robert J C |
| Συνεισφορές: | University of St Andrews.School of Medicine, University of St Andrews.Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews.Population and Behavioural Science Division, University of St Andrews.School of Psychology and Neuroscience |
| Πηγή: | The Lancet. 405:1081-1092 |
| Στοιχεία εκδότη: | Elsevier BV, 2025. |
| Έτος έκδοσης: | 2025 |
| Θεματικοί όροι: | Early detection of cancer/methods, Male, Behavior therapy/methods, 3rd-DAS, Middle Aged, Patient Acceptance of Health Care, Patient acceptance of health Care/statistics & numerical data, SDG 3 - Good Health and Well-being, Scotland, Behavior Therapy, Occult Blood, Occult blood, Mass screening/methods, Humans, Mass Screening, Female, Colorectal Neoplasms, Early Detection of Cancer, Colorectal neoplasms/diagnosis, Aged |
| Περιγραφή: | Uptake of colorectal cancer screening is suboptimal. The TEMPO trial evaluated the impact of two evidence-based, theory-informed, and co-designed behavioural interventions on uptake of faecal immunochemical test (FIT) colorectal screening.TEMPO was a 2 × 4 factorial, eight-arm, randomised controlled trial embedded in the nationwide Scottish Bowel Screening Programme. All 40 000 consecutive adults (aged 50-74 years) eligible for colorectal screening were allocated to one of eight groups using block randomisation: (1) standard invitation; (2) 1-week suggested FIT return deadline; (3) 2-week deadline; (4) 4-week deadline; (5) problem-solving planning tool (no deadline); (6) planning tool plus 1-week deadline; (7) planning tool plus 2-week deadline; (8) planning tool plus 4-week deadline. The primary outcome was the proportion of FITs returned correctly completed to be tested by the colorectal screening laboratory providing a positive or negative result, within 3 months of the FIT being mailed to a person. The trial is registered with clinicaltrials.gov, NCT05408169.From June 19 to July 3, 2022, 5000 participants were randomly assigned per group, with no loss to follow-up. 266 participants met the exclusion criteria; 39 734 (19 909 [50·1%] female and 19 825 [49·9%] male; mean age 61·2 [SD 7·3] years) were included in the analysis. The control group (no deadline, and no planning tool) had a 3-month FIT return rate of 66·0% (3275 of 4965). The highest return rate was seen with a 2-week deadline without the planning tool (3376 [68·0%] of 4964; difference vs control of 2·0% [95% CI 0·2 to 3·9]). The lowest return rate was seen when the planning tool was given without a deadline (3134 [63·2%] of 4958; difference vs control of -2·8% [-4·7 to -0·8]). The primary analysis, assuming independent effects of the two interventions, suggested a clear positive effect of giving a deadline (adjusted odds ratio [aOR] 1·13 [1·08 to 1·19]; p |
| Τύπος εγγράφου: | Article |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(24)02813-7 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/40088914 https://hdl.handle.net/10023/32406 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....e83e203b7d1cfb34bacc8e00f1b656d6 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 01406736 |
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| DOI: | 10.1016/s0140-6736(24)02813-7 |