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Multi-Responsive Amphiphilic Hyperbranched Poly[(2-dimethyl aminoethyl methacrylate)-co-(benzyl methacrylate)]copolymers: Self-Assembly and Curcumin Encapsulation in Aqueous Media

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Title: Multi-Responsive Amphiphilic Hyperbranched Poly[(2-dimethyl aminoethyl methacrylate)-co-(benzyl methacrylate)]copolymers: Self-Assembly and Curcumin Encapsulation in Aqueous Media
Authors: Foteini Ginosati, Dimitrios Vagenas, Angelica Maria Gerardos, Stergios Pispas
Contributors: © 2025 by the authors. Licensee MDPI, Basel, Switzerland.
Source: Materials (Basel)
Publisher Information: MDPI AG, 2025.
Publication Year: 2025
Subject Terms: Βιοιατρική μηχανική. Ηλεκτρονική. Ενοργάνιση, RAFT polymerization, Φασματοσκοπία, encapsulation, curcumin, self-assembly, Biomedical engineering. Electronics. Instrumentation, light scattering, Spectroscopy, Article, amphiphilic hyperbranched statistical copolymers
Description: In this study, we report the synthesis of amphiphilic hyperbranched poly[(2-dimethylaminoethyl methacrylate)-co-(benzyl methacrylate)] statistical copolymers with two different stoichiometric compositions using the reversible addition–fragmentation chain transfer polymerization (RAFT) technique. The selection of monomers was made to incorporate a pH and thermoresponsive polyelectrolyte (DMAEMA) component and a hydrophobic component (BzMA) to achieve amphiphilicity and study the effects of architecture and environmental factors on the behavior of the novel branched copolymers. Molecular characterization was performed through size exclusion chromatography (SEC) and spectroscopic characterization techniques (1H-NMR and FT-IR). The self-assembly behavior of the hyperbranched copolymers in aqueous media, in response to variations in pH, temperature, and ionic strength, was studied using dynamic light scattering (DLS), electrophoretic light scattering (ELS), and fluorescence spectroscopy (FS). Finally, the efficacy of the two novel copolymers to encapsulate curcumin (CUR), a hydrophobic, polyphenolic drug with proven anti-inflammatory and fluorescence properties, was established. Its encapsulation was evaluated through DLS, UV–Vis, and fluorescence measurements, investigating the change of hydrodynamic radius of the produced mixed copolymer–CUR nanoparticles in each case and their fluorescence emission properties.
Document Type: Article
Other literature type
Language: English
ISSN: 1996-1944
DOI: 10.3390/ma18030513
Access URL: https://pubmed.ncbi.nlm.nih.gov/39942180
Rights: CC BY
URL: https://creativecommons.org/licenses/by/4.0/deed.el
Accession Number: edsair.doi.dedup.....e57e7be16f8048e533b5a760359a7c94
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  Data: Multi-Responsive Amphiphilic Hyperbranched Poly[(2-dimethyl aminoethyl methacrylate)-co-(benzyl methacrylate)]copolymers: Self-Assembly and Curcumin Encapsulation in Aqueous Media
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  Data: <searchLink fieldCode="AR" term="%22Foteini+Ginosati%22">Foteini Ginosati</searchLink><br /><searchLink fieldCode="AR" term="%22Dimitrios+Vagenas%22">Dimitrios Vagenas</searchLink><br /><searchLink fieldCode="AR" term="%22Angelica+Maria+Gerardos%22">Angelica Maria Gerardos</searchLink><br /><searchLink fieldCode="AR" term="%22Stergios+Pispas%22">Stergios Pispas</searchLink>
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  Data: © 2025 by the authors. Licensee MDPI, Basel, Switzerland.
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  Data: In this study, we report the synthesis of amphiphilic hyperbranched poly[(2-dimethylaminoethyl methacrylate)-co-(benzyl methacrylate)] statistical copolymers with two different stoichiometric compositions using the reversible addition–fragmentation chain transfer polymerization (RAFT) technique. The selection of monomers was made to incorporate a pH and thermoresponsive polyelectrolyte (DMAEMA) component and a hydrophobic component (BzMA) to achieve amphiphilicity and study the effects of architecture and environmental factors on the behavior of the novel branched copolymers. Molecular characterization was performed through size exclusion chromatography (SEC) and spectroscopic characterization techniques (1H-NMR and FT-IR). The self-assembly behavior of the hyperbranched copolymers in aqueous media, in response to variations in pH, temperature, and ionic strength, was studied using dynamic light scattering (DLS), electrophoretic light scattering (ELS), and fluorescence spectroscopy (FS). Finally, the efficacy of the two novel copolymers to encapsulate curcumin (CUR), a hydrophobic, polyphenolic drug with proven anti-inflammatory and fluorescence properties, was established. Its encapsulation was evaluated through DLS, UV–Vis, and fluorescence measurements, investigating the change of hydrodynamic radius of the produced mixed copolymer–CUR nanoparticles in each case and their fluorescence emission properties.
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      – SubjectFull: RAFT polymerization
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      – SubjectFull: amphiphilic hyperbranched statistical copolymers
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      – TitleFull: Multi-Responsive Amphiphilic Hyperbranched Poly[(2-dimethyl aminoethyl methacrylate)-co-(benzyl methacrylate)]copolymers: Self-Assembly and Curcumin Encapsulation in Aqueous Media
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