Academic Journal
Multiple primary cancer in Leser — Trelat syndrome (description of a clinical case)
| Title: | Multiple primary cancer in Leser — Trelat syndrome (description of a clinical case) |
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| Authors: | Bondar, V. G., Kayryak, O. V., Vasiliev, V. V., Gubergrits, N. B., Mozhyna, T. L. |
| Source: | Modern Gastroenterology; № 5 (2020); 65—70 Современная гастроэнтерология; № 5 (2020); 65—70 Сучасна гастроентерологія; № 5 (2020); 65—70 |
| Publisher Information: | Publishing Company VIT-A-POL, 2020. |
| Publication Year: | 2020 |
| Subject Terms: | синдром Лезера — Трела, паранеоплазия, себорейная кератома, первично‑множественный рак, паранеоплазії, себорейна кератома, первинно‑множинний рак, Leser — Trelat syndrome, paraneoplasia, seborrheic keratoma, multiple primary cancer, 3. Good health |
| Description: | The article provides information about one of the typical paraneoplastic syndromes — Leser — Trelat syndrome, a condition that develops jointly and sometimes precedes the appearance of a malignant visceral tumor. Brief clinical characteristics of Leser — Trelat syndrome are presented. Its predominant development in elderly and senile patients has been outlined, as well as its predominant association with malignant neoplasms of the gastrointestinal tract (47.7 %), lungs, mammary glands, prostate, kidneys, liver, T‑cell lymphomas (fungal mycosis, Sesari syndrome). Possible atypical relationships of Leser — Trelat syndrome with basalioma of the lower eyelid, skin melanoma are disclosed. Cases of fast (several months) and slow (years) formation of this paraneoplastic syndrome with a typical widespread nature of the lesion and a rare focal localization of keratomas are described. A clinical case with typical manifestations of dermatological paraneoplastic syndrome in the form of Leser — Trelat syndrome in a patient with multiple primary metachronous cancer is presented: right breast cancer (T2N0M0; ER‑, PR‑, HER2neu‑; 2017), right kidney cancer (T1N0M0; 24.02.2020), cancer of the rectum and sigmoid colon (T4N0M0; 22.07.2020). Pathological signs of malignant transformation of female genitals, peripheral lymph nodes were not found. Combined treatment (surgical intervention: resection of right kidney, combined resection of sigmoid colon, extirpation of uterus with appendages, polypectomy of colon in combination with a course of chemotherapy in a neoadjuvant mode) facilitated the resolution of seborrheic adenomas, which confirmed the paraneoplastic nature of Leser — Trelat syndrome. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| ISSN: | 2521-649X 1727-5725 |
| DOI: | 10.30978/mg-2020-5-65 |
| Access URL: | http://sgastro.com.ua/article/view/MG-2020-5-65 |
| Accession Number: | edsair.doi.dedup.....e49694b64d2907470a8cf7dc2bc0e4d4 |
| Database: | OpenAIRE |
| ISSN: | 2521649X 17275725 |
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| DOI: | 10.30978/mg-2020-5-65 |