Academic Journal
Altered brain network dynamics in motor functional neurological disorders: The role of the right temporo-parietal junction
| Title: | Altered brain network dynamics in motor functional neurological disorders: The role of the right temporo-parietal junction |
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| Authors: | Samantha Weber, Janine Bühler, Thomas A. W. Bolton, Selma Aybek |
| Source: | Transl Psychiatry Translational Psychiatry, Vol 15, Iss 1, Pp 1-9 (2025) Translational psychiatry, vol. 15, no. 1, pp. 167 |
| Publisher Information: | Springer Science and Business Media LLC, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Male, Adult, Brain Mapping, Default Mode Network, Neurosciences. Biological psychiatry. Neuropsychiatry, Middle Aged, Humans, Female, Parietal Lobe/physiopathology, Parietal Lobe/diagnostic imaging, Temporal Lobe/physiopathology, Temporal Lobe/diagnostic imaging, Magnetic Resonance Imaging, Nerve Net/physiopathology, Nerve Net/diagnostic imaging, Case-Control Studies, Aged, Nervous System Diseases/physiopathology, Nervous System Diseases/diagnostic imaging, Default Mode Network/physiopathology, Default Mode Network/diagnostic imaging, Executive Function/physiology, Article, Temporal Lobe, Executive Function, Parietal Lobe, Nerve Net, Nervous System Diseases, RC321-571 |
| Description: | Functional neurological disorders’ (FND) neuropathophysiology has been described as multi-network disturbances including aberrancies in the agency network highlighting the role of the right temporo-parietal junction (rTPJ). Refining the relevance of the rTPJ. we applied a co-activation pattern (CAP) based approach using the rTPJ as seed in 58 patients with motor FND compared to 58 age- and sex-matched healthy controls. Firstly, CAPs were derived from HC to identify functional alteration in the rTPJ network in FND patients. Secondly, motor subgroup characteristics in patients were examined using CAPs derived from the patient group. Compared to HC, patients were found to enter less frequently a state characterized by salience network and default mode network (DMN) co-activation along with executive control and somatomotor networks co-deactivation. Additionally, patients entered more often a state depicted by somatomotor-salience co-activation and DMN co-deactivation. Comparing motor subgroups, patients with functional weakness remained longer in a state characterised by attention network co-activation and DMN co-deactivation compared to patients with no functional weakness. FND patients overall exhibited a reduced coupling of the DMN and an increased coupling of the somatomotor network with the rTPJ compared to controls. Patient subgroups differed regarding coupling between rTPJ to attention network and DMN. rTPJ dynamic network alterations might reflect hampered flexibility in brain state switching and altered self-referential processes linked to impaired motor planning and execution, which seems to also differ between symptom types, indicating a potential phenotypic biomarker. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| ISSN: | 2158-3188 |
| DOI: | 10.21203/rs.3.rs-4294300/v1 |
| DOI: | 10.1038/s41398-025-03385-5 |
| DOI: | 10.48620/84907 |
| DOI: | 10.48620/88388 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/40374624 https://doaj.org/article/8d2ab1125c104c389fcade0f00d714af http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_61AFCDBA37CD8 https://serval.unil.ch/notice/serval:BIB_61AFCDBA37CD https://serval.unil.ch/resource/serval:BIB_61AFCDBA37CD.P001/REF.pdf |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....e2f2ba7342780aa89f7c23378e8e8c68 |
| Database: | OpenAIRE |
| ISSN: | 21583188 |
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| DOI: | 10.21203/rs.3.rs-4294300/v1 |