Academic Journal
Association Between MScanFit Motor Unit Number Estimation and Clinical Function and Response to Immunoglobulin Therapy in Chronic Inflammatory Demyelinating Polyneuropathy
| Τίτλος: | Association Between MScanFit Motor Unit Number Estimation and Clinical Function and Response to Immunoglobulin Therapy in Chronic Inflammatory Demyelinating Polyneuropathy |
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| Συγγραφείς: | Peter N. Hansen, Abdullahi A. Mohammed, Lars K. Markvardsen, Henning Andersen, Hatice Tankisi, Søren H. Sindrup, Thomas Krøigård |
| Πηγή: | J Peripher Nerv Syst Hansen, P N, Mohammed, A A, Markvardsen, L K, Andersen, H, Tankisi, H, Sindrup, S H & Krøigård, T 2025, 'Association Between MScanFit Motor Unit Number Estimation and Clinical Function and Response to Immunoglobulin Therapy in Chronic Inflammatory Demyelinating Polyneuropathy', Journal of the Peripheral Nervous System, vol. 30, no. 1, e70001. https://doi.org/10.1111/jns.70001 |
| Στοιχεία εκδότη: | Wiley, 2025. |
| Έτος έκδοσης: | 2025 |
| Θεματικοί όροι: | Research Report, Male, Adult, Action Potentials/physiology, Polyradiculoneuropathy, Neural Conduction, Immunoglobulins, Action Potentials, axonal loss, chronic inflammatory demyelinating polyneuropathy, motor unit number estimation, Humans, Immunologic Factors, MScanFit, Muscle, Skeletal, Aged, Motor Neurons, Electromyography, Chronic Inflammatory Demyelinating/physiopathology, Neural Conduction/physiology, Immunoglobulins, Intravenous, Middle Aged, Intravenous/administration & dosage, Treatment Outcome, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Motor Neurons/physiology, Muscle, Female, Skeletal/physiopathology, immunoglobulin, Immunologic Factors/administration & dosage |
| Περιγραφή: | Background and AimsLoss of motor units in chronic inflammatory demyelinating polyneuropathy is difficult to assess by conventional nerve conduction due to collateral innervation. We aimed to assess the association between a motor unit number estimate (MUNE) derived from the compound muscle action potential (CMAP) scan using MScanFit and hand function and the clinical response to intravenous immunoglobulin (IVIG).MethodsForty‐nine CIDP patients and 52 control subjects were included. CMAP scan recordings were obtained from the right abductor pollicis brevis muscle. The primary outcome was the correlation between MUNE and the duration of the nine‐hole‐peg test (9‐HPT) at baseline and the change in the duration of the 9‐HPT following treatment with IVIG. Secondary outcomes were grip strength, 10‐m‐walk test, six‐spot‐step test, medical research council sum score, inflammatory neuropathy cause and treatment sensory sum score, overall neuropathy limitations scale, and the Rasch‐built overall disability scale (R‐ODS).ResultsMScanFit analysis suggested both loss of motor units (reduced MUNE (p = 0.022) and N50 (p p p r = −0.342; p = 0.016). Further, patients with a low MUNE had the largest reduction in the duration of the 9‐HPT following IVIG treatment (r = −0.577; p = 0.043). MUNE also correlated significantly with R‐ODS (r = −0.722; p = 0.007).InterpretationMScanFit MUNE could be a useful method for assessing motor axonal loss in CIDP, which correlates with the clinical function and treatment response. |
| Τύπος εγγράφου: | Article Other literature type |
| Γλώσσα: | English |
| ISSN: | 1529-8027 1085-9489 |
| DOI: | 10.1111/jns.70001 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/39887824 https://portal.findresearcher.sdu.dk/da/publications/df2017a0-5f75-452e-9a16-8111041b4f6e https://doi.org/10.1111/jns.70001 https://pure.au.dk/portal/en/publications/b7bc708f-1c91-4cdf-8536-feffee0a56fc https://doi.org/10.1111/jns.70001 http://www.scopus.com/inward/record.url?scp=85216664395&partnerID=8YFLogxK |
| Rights: | CC BY NC ND URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....dfb5f8717f871817d81ff89875d7ce65 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 15298027 10859489 |
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| DOI: | 10.1111/jns.70001 |