Academic Journal
Definition and diagnosis of Parkinson’s disease: guideline 'Parkinson’s disease' of the German Society of Neurology
| Title: | Definition and diagnosis of Parkinson’s disease: guideline 'Parkinson’s disease' of the German Society of Neurology |
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| Authors: | Hopfner, Franziska, Höglinger, Günter, German Parkinson’s Guidelines Group, Bähr, Mathias, Becktepe, Jos, Berg, Daniela, Brockmann, Kathrin, Ceballos-Baumann, Andrés, Claßen, Joseph, Deuschl, Cornelius, Deuschl, Günther, Dodel, Richard, Ebersbach, Georg, Eggers, Carsten, van Eimeren, Thilo, Fanciulli, Alessandra, Fimm, Bruno, Folkerts, Ann-Kristin, Gausepohl, Madeleine, Hasan, Alkomiet, Hermann, Wiebke, Hilker-Roggendorf, Rüdiger, Höllerhage, Matthias, Jost, Wolfgang, Kalbe, Elke, Kassubek, Jan, Klebe, Stephan, Klein, Christine, Klietz, Martin, Köglsperger, Thomas, Kühn, Andrea, Krack, Paul, Krismer, Florian, Kuhlenbäumer, Gregor, Levin, Johannes, Liepelt-Scarfone, Inga, Lingor, Paul, Loewenbrück, Kai, Löhle, Matthias, Maaß, Sylvia, Maetzler, Walter, Menzel, Regina, Meyer, Philipp T, Mollenhauer, Brit, Neumann, Manuela, Odin, Per, Outeiro, Tiago, Pötter-Nerger, Monika, Reese, René, Reetz, Kathrin, Rieß, Olaf, Ruf, Viktoria, Schneider, Anja, Schrader, Christoph, Schnitzler, Alfons, Seppi, Klaus, Sixel-Döring, Friederike, Storch, Alexander, Tönges, Lars, Walter, Uwe, Wächter, Tobias, Warnecke, Tobias, Wegner, Florian, Winkler, Christian, Witt, Karsten, Woitalla, Dirk, Zeuner, Kirsten, Trenkwalder, Claudia |
| Contributors: | Deuschl, Cornelius, Deuschl, Günther, Dodel, Richard, Ebersbach, Georg, Eggers, Carsten, Eimeren, Thilo, Fanciulli, Alessandra, Fimm, Bruno, Folkerts, Ann-Kristin, Gausepohl, Madeleine, Hasan, Alkomiet, Hermann, Wiebke, Hilker-Roggendorf, Rüdiger, Höllerhage, Matthias, Jost, Wolfgang, Kalbe, Elke, Kassubek, Jan, Klebe, Stephan, Klein, Christine, Klietz, Martin, Köglsperger, Thomas, Kühn, Andrea, Krack, Paul, Krismer, Florian, Kuhlenbäumer, Gregor, Levin, Johannes, Liepelt-Scarfone, Inga, Lingor, Paul, Loewenbrück, Kai, Löhle, Matthias, Bähr, Mathias, Maaß, Sylvia, Maetzler, Walter, Menzel, Regina, Meyer, Philipp T, Mollenhauer, Brit, Neumann, Manuela, Odin, Per, Outeiro, Tiago, Pötter-Nerger, Monika, Reese, René, Becktepe, Jos, Reetz, Kathrin, Rieß, Olaf, Ruf, Viktoria, Schneider, Anja, Schrader, Christoph, Schnitzler, Alfons, Seppi, Klaus, Sixel-Döring, Friederike, Storch, Alexander, Tönges, Lars, Berg, Daniela, Walter, Uwe, Wächter, Tobias, Warnecke, Tobias, Wegner, Florian, Winkler, Christian, Witt, Karsten, Woitalla, Dirk, Zeuner, Kirsten, Brockmann, Kathrin, Ceballos-Baumann, Andrés, Claßen, Joseph, Hopfner, Franziska, Höglinger, Günter, Trenkwalder, Claudia, German Parkinson’s Guidelines Group |
| Source: | J Neurol Journal of neurology 271(11), 7102-7119 (2024). doi:10.1007/s00415-024-12687-5 |
| Publisher Information: | Springer Science and Business Media LLC, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Parkinson Disease, Definition, Review, Imaging, Neurology, Germany, standards [Neurology], standards [Practice Guidelines as Topic], standards [Societies, Medical], Diagnosis, Practice Guidelines as Topic, Genetics, Parkinson's disease, Humans, Biomarkers, Systematic Reviews as Topic [MeSH], Humans [MeSH], Practice Guidelines as Topic/standards [MeSH], Parkinson Disease/diagnosis [MeSH], Neurology/standards [MeSH], Societies, Medical/standards [MeSH], Germany [MeSH], ddc:610, diagnosis [Parkinson Disease], Societies, Medical, Systematic Reviews as Topic |
| Description: | Background Accurate definition and operational criteria for diagnosing Parkinson’s disease (PD) are crucial for evidence-based, patient-centered care. Objective To offer evidence-based recommendations for defining and diagnosing PD, incorporating contemporary clinical, imaging, biomarker, and genetic insights. Methods The guideline development began with the steering committee establishing key PICO (patient, intervention, comparison, outcome) questions, which were refined by the coauthors. Systematic literature searches identified relevant studies, reviews, and meta-analyses. Recommendations were drafted, evaluated, optimized, and voted upon by the German Parkinson’s Guideline Group. Results Parkinson’s disease (PD) is now understood to encompass a broader spectrum of etiologies than previously recognized. Advances in molecular pathogenesis, neuroimaging, and early clinical phenotypes suggest that PD is not a uniform disease entity and is often not idiopathic. This necessitates an updated framework for PD definition and diagnosis. The German Society for Neurology now endorses a broader concept of PD, incorporating both idiopathic and hereditary forms, as opposed to the previously narrower concept of “idiopathic Parkinson syndrome.” The revised guidelines recommend using the 2015 Movement Disorders Society diagnostic criteria, emphasize the importance of long-term clinical follow-up for improved diagnostic accuracy, and highlight the significance of non-motor symptoms in clinical diagnosis. Specific recommendations are provided for the use of imaging and fluid biomarkers and genetic testing to support the clinical diagnosis. Conclusion The updated guidelines from the German Society for Neurology enhance diagnostic accuracy for PD, promoting optimized clinical care. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1432-1459 0340-5354 |
| DOI: | 10.1007/s00415-024-12687-5 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/39297986 https://pub.dzne.de/record/275850 https://resolver.sub.uni-goettingen.de/purl?gro-2/145672 https://repository.publisso.de/resource/frl:6503867 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....d619285973648584202ef53b1bccdfdd |
| Database: | OpenAIRE |
| ISSN: | 14321459 03405354 |
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| DOI: | 10.1007/s00415-024-12687-5 |