Academic Journal
EFFICACY AND TOLERABILITY OF GENERIC ZOLEDRONIC ACID 5 MG (REZOCLASTIN PS) IN THE TREATMENT OF OSTEOPOROSIS: A RETROSPECTIVE ANALYSIS OF CLINICAL EXPERIENCE WITH THE DRUG IN RUSSIA
| Title: | EFFICACY AND TOLERABILITY OF GENERIC ZOLEDRONIC ACID 5 MG (REZOCLASTIN PS) IN THE TREATMENT OF OSTEOPOROSIS: A RETROSPECTIVE ANALYSIS OF CLINICAL EXPERIENCE WITH THE DRUG IN RUSSIA |
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| Authors: | L A Marchenkova, A V Dreval, I V Baharev |
| Source: | Остеопороз и остеопатии, Vol 17, Iss 3, Pp 22-26 (2014) |
| Publisher Information: | Endocrinology Research Centre, 2014. |
| Publication Year: | 2014 |
| Subject Terms: | Osteopathy, золедроновая кислота, 03 medical and health sciences, бисфосфонаты, 0302 clinical medicine, дженерик, RZ301-397.5, остеопороз, 3. Good health |
| Description: | Objectives. To analyze clinical data of the first domestic zoledronic acid generic preparation for the treatment of osteoporosis (Rezoclastin PS., 5 mg). Materials and Methods. The study included data from 123 patients (118 women and 5 men) treated with Rezoclastin PS 5 mg in medical centers of Moscow, St.-Petersburg and Krasnodar for primary (91.8%) or secondary(8.2%) osteoporosis, with mean age 27-78 years (61,4 ± 9,1 years). 56.6% of patients had severe osteoporosis with compressive deformations of vertebrae. Duration of medical therapy ranged from 6 to 24 months. Results. Study of changers in bone resorption marker CTx (n = 10) showed decline by 78% after 3 months of treatment compared to baseline (p = 0.027). BMD at the lumbar segment of the spine L 1-L 4 increased after 12 months by 3.4% (p |
| Document Type: | Article Other literature type |
| ISSN: | 2311-0716 2072-2680 |
| DOI: | 10.14341/osteo2014322-26 |
| Access URL: | https://doaj.org/article/d157cdd3e35e4c17ae29bf5075c34b60 https://www.osteo-endojournals.ru/jour/article/view/8891 https://www.osteo-endojournals.ru/jour/article/download/8891/6517 https://cyberleninka.ru/article/n/effektivnost-i-perenosimost-rezoklastina-fs-5-mg-pri-lechenii-osteoporoza-retrospektivnyy-analiz-klinicheskogo-opyta-primeneniya https://cyberleninka.ru/article/n/effektivnost-i-perenosimost-rezoklastina-fs-5-mg-pri-lechenii-osteoporoza-retrospektivnyy-analiz-klinicheskogo-opyta-primeneniya/pdf https://core.ac.uk/display/158391577 |
| Rights: | CC BY NC SA |
| Accession Number: | edsair.doi.dedup.....d36cd0d1d53e9ebb0fbd3de5e90c67b3 |
| Database: | OpenAIRE |
| ISSN: | 23110716 20722680 |
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| DOI: | 10.14341/osteo2014322-26 |