Academic Journal
Methodological aspects of health‐related quality of life measurement and analysis in patients with multiple myeloma
| Title: | Methodological aspects of health‐related quality of life measurement and analysis in patients with multiple myeloma |
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| Authors: | Tobias Wirenfeldt Klausen, Niels Abildgaard, Lene Kongsgaard Nielsen, Mary Jarden |
| Source: | Nielsen, L K, Abildgaard, N, Jarden, M & Klausen, T W 2019, ' Methodological aspects of health-related quality of life measurement and analysis in patients with multiple myeloma ', British Journal of Haematology, vol. 185, no. 1, pp. 11-24 . https://doi.org/10.1111/bjh.15759 Kongsgaard Nielsen, L, Abildgaard, N, Jarden, M E & Klausen, T W 2019, ' Methodological aspects of health-related quality of life measurement and analysis in patients with multiple myeloma ', British Journal of Haematology, vol. 185, no. 1, pp. 11-24 . https://doi.org/10.1111/bjh.15759 |
| Publisher Information: | Wiley, 2019. |
| Publication Year: | 2019 |
| Subject Terms: | Clinical Trials as Topic, Clinical Trials as Topic/statistics & numerical data, Multiple Myeloma/drug therapy, review, Datasets as Topic, Patient Acceptance of Health Care, Multicenter Studies as Topic/statistics & numerical data, 3. Good health, health-related quality of life, multiple myeloma, missing data, 03 medical and health sciences, Treatment Outcome, 0302 clinical medicine, statistical analysis, Surveys and Questionnaires, Quality of Life, Humans, Multicenter Studies as Topic, Patient Reported Outcome Measures, Multiple Myeloma, Attitude to Health |
| Description: | SummaryMultiple myeloma (MM) is an incurable but treatment‐sensitive cancer. For most patients, this means treatment with multiple lines of anti‐myeloma therapy and a life with disease‐ and treatment‐related symptoms and complications. Health‐related quality of life (HRQoL) issues play an important role in treatment decision‐making. Methodological challenges in longitudinal HRQoL measurements and analyses have been identified, including non‐responses (NR) to scheduled questionnaires. Publications were identified for inclusion in a systematic review of longitudinal HRQoL studies in MM, focussing on methodological aspects of HRQoL measurement and analysis. Diversity in timing of HRQoL data collection and applied statistical methods were noted. We observed a high rate of NR, but the impact of NR was investigated in only 8/23 studies. Thus, evidence‐based knowledge of HRQoL in patients with MM is compromised. To improve quality of HRQoL results and their implementation in daily practice, future studies should follow established guidelines. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/bjh.15759 |
| Access URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15759 https://pubmed.ncbi.nlm.nih.gov/30656677 https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.15759 https://www.ncbi.nlm.nih.gov/pubmed/30656677 https://portal.findresearcher.sdu.dk/da/publications/methodological-aspects-of-health-related-quality-of-life-measurem https://europepmc.org/article/MED/30656677 https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.15759 https://findresearcher.sdu.dk:8443/ws/files/170612811/bjh.15759.pdf https://curis.ku.dk/ws/files/249629613/Methodological_aspects_of_health_related_quality_of_life_measurement_and_analysis_in_patients_with_multiple_myeloma_accepted_version_.pdf https://findresearcher.sdu.dk:8443/ws/files/170612811/bjh.15759.pdf https://portal.findresearcher.sdu.dk/da/publications/0a9bc421-ba97-4e53-91aa-7042db748453 https://doi.org/10.1111/bjh.15759 |
| Rights: | Wiley Online Library User Agreement |
| Accession Number: | edsair.doi.dedup.....cecf6b0da1ed4c3816d5869fe2d9bbe4 |
| Database: | OpenAIRE |
| ISSN: | 13652141 00071048 |
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| DOI: | 10.1111/bjh.15759 |