Academic Journal
Improving neurophysiological biomarkers for functional myoclonic movements
| Τίτλος: | Improving neurophysiological biomarkers for functional myoclonic movements |
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| Συγγραφείς: | Beudel, M, Zutt, R, Meppelink, AM, Little, S, Elting, JW, Stelten, BML, Edwards, M, Tijssen, MAJ |
| Πηγή: | Parkinsonism Relat Disord |
| Στοιχεία εκδότη: | Elsevier BV, 2018. |
| Έτος έκδοσης: | 2018 |
| Θεματικοί όροι: | Adult, Male, Myoclonus, Adolescent, Clinical Sciences, Electroencephalography Phase Synchronization, Contingent Negative Variation, Contingent Negative Variation/physiology, Electroencephalography Phase Synchronization/physiology, Article, Electroencephalography/standards, Young Adult, Functional myoclonic jerks, Clinical Research, Beta Rhythm/physiology, Neurophysiological biomarkers, Journal Article, Humans, Child, Event related desynchronisation, Aged, Neurology & Neurosurgery, Bereitschaftspotential, Electroencephalography, Middle Aged, Myoclonus/diagnosis, Cognitive Sciences, Female, Beta Rhythm, Biomarkers |
| Περιγραφή: | Differentiating between functional jerks (FJ) and organic myoclonus can be challenging. At present, the only advanced diagnostic biomarker to support FJ is the Bereitschaftspotential (BP). However, its sensitivity is limited and its evaluation subjective. Recently, event related desynchronisation in the broad beta range (13-45 Hz) prior to functional generalised axial (propriospinal) myoclonus was reported as a possible complementary diagnostic marker for FJ. Here we study the value of ERD together with a quantified BP in clinical practice.Twenty-nine patients with FJ and 16 patients with cortical myoclonus (CM) were included. Jerk-locked back-averaging for determination of the 'classical' and quantified BP, and time-frequency decomposition for the event related desynchronisation (ERD) were performed. Diagnostic gain, sensitivity and specificity were obtained for individual and combined techniques.We detected a classical BP in 14/29, a quantitative BP in 15/29 and an ERD in 18/29 patients. At group level we demonstrate that ERD in the broad beta band preceding a jerk has significantly higher amplitude in FJ compared to CM (respectively -0.14 ± 0.13 and +0.04 ± 0.09 (p |
| Τύπος εγγράφου: | Article Conference object Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2018.03.029 |
| Σύνδεσμος πρόσβασης: | http://www.prd-journal.com/article/S1353802018301445/pdf https://pubmed.ncbi.nlm.nih.gov/29653908 https://openaccess.sgul.ac.uk/id/eprint/109934/7/1-s2.0-S1353802018301445-main.pdf https://hdl.handle.net/11370/e5157b65-ba1c-4e5d-bbd6-7a72de868f9f https://doi.org/10.1016/j.parkreldis.2018.03.029 https://research.rug.nl/en/publications/e5157b65-ba1c-4e5d-bbd6-7a72de868f9f https://www.sciencedirect.com/science/article/abs/pii/S1353802018301445 https://www.narcis.nl/publication/RecordID/oai%3Apure.rug.nl%3Apublications%2Fe5157b65-ba1c-4e5d-bbd6-7a72de868f9f https://core.ac.uk/display/159597720 https://www.ncbi.nlm.nih.gov/pubmed/29653908 https://discovery.ucl.ac.uk/id/eprint/10046258/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022215/ https://discovery-pp.ucl.ac.uk/id/eprint/10046258/ https://escholarship.org/content/qt7cp8s2z2/qt7cp8s2z2.pdf https://escholarship.org/uc/item/7cp8s2z2 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....cc446bd675842917b257eaae83da68d8 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 13538020 |
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| DOI: | 10.1016/j.parkreldis.2018.03.029 |