Academic Journal
Sex differences in the association of Alzheimer’s disease biomarkers and cognition in a multicenter memory clinic study
| Τίτλος: | Sex differences in the association of Alzheimer’s disease biomarkers and cognition in a multicenter memory clinic study |
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| Συγγραφείς: | Boccalini, Cecilia, Peretti, Debora Elisa, Scheffler, Max, Mu, Linjing, Griffa, Alessandra, Testart, Nathalie, Allali, Gilles, Prior, John O., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Frisoni, Giovanni B., Garibotto, Valentina |
| Πηγή: | Alzheimers Res Ther Alzheimer’s Research & Therapy, Vol 17, Iss 1, Pp 1-11 (2025) Alzheimer's research & therapy, vol. 17, no. 1, pp. 46 ALZHEIMERS RESEARCH & THERAPY, 17 (1) |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2025. |
| Έτος έκδοσης: | 2025 |
| Θεματικοί όροι: | Male, tau-PET, Humans, Female, Alzheimer Disease/diagnostic imaging, Alzheimer Disease/metabolism, Alzheimer Disease/psychology, Biomarkers/blood, Biomarkers/metabolism, Aged, tau Proteins/metabolism, Sex Characteristics, Cognition/physiology, Glial Fibrillary Acidic Protein/blood, Magnetic Resonance Imaging, Positron-Emission Tomography, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/metabolism, Aged, 80 and over, Amyloid beta-Peptides/metabolism, Middle Aged, Sex Factors, Alzheimer's disease, Biomarkers, Neuroimaging, Sex, Women, Neurosciences. Biological psychiatry. Neuropsychiatry, tau Proteins, Neuropsychological Tests, Cognition, Alzheimer Disease, Glial Fibrillary Acidic Protein, Cognitive Dysfunction, RC346-429, Amyloid beta-Peptides, Research, Neurology. Diseases of the nervous system, RC321-571 |
| Περιγραφή: | Background This study investigated sex differences in the associations between Alzheimer’s disease (AD) biomarkers, cognitive performance, and decline in memory clinic settings. Methods 249 participants (females/males:123/126), who underwent tau-PET, amyloid-PET, structural MRI, and plasma glial fibrillary acidic protein (GFAP) measurement were included from Geneva and Lausanne Memory Clinics. Mann-Whitney U tests investigated sex differences in clinical and biomarker data. Linear regression models estimated the moderating effect of sex on the relationship between biomarkers and cognitive performance and decline. Sex differences in cognitive decline were further evaluated using longitudinal linear mixed-effect models with three-way interaction effects. Results Women and men present similar clinical features, amyloid, and neurodegeneration. Women had higher tau load and plasma levels of GFAP than men (p p p p p = 0.047), whereas the associations between tau and cognition and between tau and neurodegeneration were stronger among men than in women (standardized β=-0.76,p = 0.001 and standardized β=-0.56,p = 0.044). Women exhibited faster cognitive decline than men in the presence of severe cortical thinning (p Conclusion Women showed higher tau load and stronger association between amyloid and tau than men. In individuals with high tau burden, men exhibited greater neurodegeneration and cognitive impairment than women. These findings support that sex differences may impact tau deposition through an upstream interplay with amyloid, leading to downstream effects on neurodegeneration and cognitive outcomes. |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf; application/application/pdf |
| Γλώσσα: | English |
| ISSN: | 1758-9193 |
| DOI: | 10.1186/s13195-025-01684-z |
| DOI: | 10.3929/ethz-b-000724750 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/39966925 https://doaj.org/article/ad1d015d9d584c47bfd2d0613b074491 https://serval.unil.ch/notice/serval:BIB_38E2DE99CC3C http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_38E2DE99CC3C9 https://serval.unil.ch/resource/serval:BIB_38E2DE99CC3C.P001/REF.pdf http://hdl.handle.net/20.500.11850/724750 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....c9d232acc921a86e54db88b4b8204bbf |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 17589193 |
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| DOI: | 10.1186/s13195-025-01684-z |