Academic Journal
Neonatal seizures: Is there a relationship between ictal electroclinical features and etiology? A critical appraisal based on a systematic literature review
| Title: | Neonatal seizures: Is there a relationship between ictal electroclinical features and etiology? A critical appraisal based on a systematic literature review |
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| Authors: | Nunes, ML, Yozawitz, EG, Zuberi, S, Mizrahi, EM, Cilio, MR, Moshé, SL, Plouin, P, Vanhatalo, S, Pressler, RM, Task Force on Neonatal Seizures, ILAE Commission on Classificati |
| Contributors: | UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de neurologie pédiatrique, Department of Neurosciences, Kliinisen neurofysiologian yksikkö, HUS Medical Imaging Center |
| Source: | Epilepsia Open Epilepsia open, Vol. 4, no.1, p. 10-29 (2019) |
| Publisher Information: | Wiley, 2019. |
| Publication Year: | 2019 |
| Subject Terms: | electroclinical features, semiology, neonatal seizures, Neurosciences, neonatal EEG, Neonatal seizures, Neurology and psychiatry, 3. Good health, Semiology, 03 medical and health sciences, 0302 clinical medicine, Electroclinical features, Critical Review and Invited Commentary, Neonatal EEG |
| Description: | SummaryThe aim of this study was to evaluate whether specific etiologies of neonatal seizures have distinct ictal electroclinical features. A systematic review of English articles using the PubMed database since 2004 (last update 9/26/16). Search terms included text words and Medical Subject Headings (MeSH)terms related to neonatal seizures. Eligible articles included reports of neonates with seizures with a full description of seizure semiology and electroclinical findings. Independent extraction of data was performed by 2 authors using predefined data fields, including study quality indicators. Data were collected for every individual patient described in the articles. The dataset was analyzed with the Fisher exact test. The initial search led to 8507 titles; using filters, 2910 titles and abstracts were identified, with 177 full texts selected to be read. Fifty‐seven studies were included in the analysis with 151 neonates (37.7 male and 62.9% term). Genetic etiologies (51%) and sequential seizures (41.1%) predominated in this sample and hypoxic‐ischemic encephalopathy (HIE) accounted for only 4%. The low prevalence ofHIEobserved was probably due to a publication bias. A significant association was found between etiology and seizure type: hemorrhage with autonomic seizures (P = 0.003),central nervous system (CNS)infection and stroke with clonic seizures (P = 0.042,P P EEG)patterns seen with certain etiologies: vascular disorders and electrolyte imbalance with focal ictal discharges (P P = 0.049 respectively), vitamin‐related disorders with multifocal (P = 0.003), and all categories of genetic disorders with burst‐suppression (P EEGabnormalities (P = 0.001 andP P = 0.001,P = 0.005). In conclusion, our data suggest that specific associations of etiologies of neonatal seizures with distinct clinical features andEEGpatterns might help in the decision to establish appropriate treatment. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2470-9239 |
| DOI: | 10.1002/epi4.12298 |
| Access URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/epi4.12298 https://pubmed.ncbi.nlm.nih.gov/30868112 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398099/ https://onlinelibrary.wiley.com/doi/pdf/10.1002/epi4.12298 https://pubmed.ncbi.nlm.nih.gov/30868112/ https://onlinelibrary.wiley.com/doi/full/10.1002/epi4.12298 https://einstein.pure.elsevier.com/en/publications/neonatal-seizures-is-there-a-relationship-between-ictal-electrocl https://researchportal.helsinki.fi/fi/publications/neonatal-seizures-is-there-a-relationship-between-ictal-electro-c https://hdl.handle.net/2078.1/224453 http://hdl.handle.net/10138/301738 https://discovery-pp.ucl.ac.uk/id/eprint/10074655/ |
| Rights: | CC BY NC ND |
| Accession Number: | edsair.doi.dedup.....c892d53db51e58e4e39b09917362042d |
| Database: | OpenAIRE |
| ISSN: | 24709239 |
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| DOI: | 10.1002/epi4.12298 |