Academic Journal
Denosumab and bisphosphonate associated bilateral osteonecrosis of the external auditory canal
| Title: | Denosumab and bisphosphonate associated bilateral osteonecrosis of the external auditory canal |
|---|---|
| Authors: | Harry David True, Rupert George Ricks, Joel Anthony Smith |
| Source: | Drug and Therapeutics Bulletin. 61:61-63 |
| Publisher Information: | BMJ, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | calcium and bone, Bone Density Conservation Agents, Diphosphonates, ear, Ear Canal/diagnostic imaging, nose and throat/otolaryngology, 3. Good health, otolaryngology / ENT, Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnostic imaging/surgery, otitis, Humans, Bisphosphonate-Associated Osteonecrosis of the Jaw, Female, unwanted effects / adverse reactions, Denosumab, Denosumab/adverse effects, Cholesteatoma, Ear Canal, Aged |
| Description: | We present a case of non-surgically managed bilateral osteonecrosis of the external auditory canal with a history of long-term medical therapy for osteoporosis. A 79-year-old woman with severe osteoporosis and destructive osteoarthritis received >10 years of once weekly bisphosphonate therapy before switching to denosumab. Four months later, the patient presented with bilateral loss of hearing and right-sided otalgia. Necrotising otitis externa, cholesteatoma and malignancy were considered but with histology, microbiological and CT assessment, bilateral osteonecrosis of the external auditory canal was diagnosed. Surgical debridement with canalplasty was avoided due to our patient’s comorbidities. Treatment continued for 5 months with regular aural toilet, Terra-Cortril ointment and bismuth-iodine-paraffin paste packing. At 1-year follow-up, bilateral external auditory canals were completely re-epithelialised with no pain or affected hearing. We report the first case of bilateral osteonecrosis of the external auditory canal associated with denosumab and bisphosphonates with successful conservative management. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1755-5248 0012-6543 |
| DOI: | 10.1136/dtb.2022.241203rep |
| DOI: | 10.1136/bcr-2020-241203 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/34130974 https://pubmed.ncbi.nlm.nih.gov/36008096 https://pubmed.ncbi.nlm.nih.gov/34130974/ https://casereports.bmj.com/content/14/6/e241203 https://europepmc.org/article/MED/34130974 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208004 https://casereports.bmj.com/content/bmjcr/14/6/e241203.full.pdf |
| Accession Number: | edsair.doi.dedup.....c6b77cf0ffb4fbfa6f5f37d683c9bfe0 |
| Database: | OpenAIRE |
| ISSN: | 17555248 00126543 |
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| DOI: | 10.1136/dtb.2022.241203rep |