Academic Journal
Functional network abnormalities consistent with behavioral profile in Autism Spectrum Disorder
| Title: | Functional network abnormalities consistent with behavioral profile in Autism Spectrum Disorder |
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| Authors: | Anton J.A. de Louw, AG Anton Tijhuis, Britt E. J. Michels, Jan W. M. Bergmans, Stephan Heunis, Bert Aldenkamp, René M.H. Besseling, Rolf Lamerichs |
| Source: | Psychiatry Research: Neuroimaging. 275:43-48 |
| Publisher Information: | Elsevier BV, 2018. |
| Publication Year: | 2018 |
| Subject Terms: | Male, Connectome/methods, Adolescent, Autism Spectrum Disorder, CHILDREN, SDG 3 – Goede gezondheid en welzijn, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Connectome, BRAIN ACTIVATION, Humans, Asperger Syndrome, Child, EPILEPSY, Autism Spectrum Disorder/diagnostic imaging, Brain, Brain/diagnostic imaging, Nerve Net/diagnostic imaging, Magnetic Resonance Imaging, 13. Climate action, FMRI, Female, Asperger Syndrome/diagnostic imaging, Nerve Net, BOLD |
| Description: | Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which the severity of symptoms varies over subjects. The iCAPs model (innovation-driven co-activation patterns) is a recently developed spatio-temporal model to describe fMRI data. In this study, the iCAPs model was employed to find functional imaging biomarkers for ASD in resting-state fMRI data. MRI data from 125 ASD patients and 243 healthy controls was selected from the online ABIDE data repository. Following standard fMRI preprocessing steps, the iCAP patterns were fitted to the data to obtain network time series. Furthermore, specific combinations of iCAPs were mapped to behavioral domain time series. To quantify to which extent the time series contribute to the fMRI dynamics, their (temporal) standard deviation was calculated and compared between patients and controls. Abnormalities were found in networks involving subcortical and limbic areas and default mode network regions. When mapping the network dynamics to behavioral domain time series, abnormalities were found in emotional and visual behavioral subdomains, and within the ASD spectrum were more pronounced in subjects with autism compared to Asperger's syndrome. Also a trend towards impairment in networks facilitating social cognition was found. The functional imaging abnormalities are consistent with the behavioral impairments typical for ASD. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2018.02.006 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/29628271 https://research.tue.nl/en/publications/04878d83-4500-486e-b1c0-126de03ea1e0 https://doi.org/10.1016/j.pscychresns.2018.02.006 https://cris.maastrichtuniversity.nl/en/publications/fadbb9e6-9bf4-420f-bc30-98a6561c6f08 https://doi.org/10.1016/j.pscychresns.2018.02.006 https://pubmed.ncbi.nlm.nih.gov/29628271/ https://www.narcis.nl/publication/RecordID/oai%3Apure.tue.nl%3Apublications%2F04878d83-4500-486e-b1c0-126de03ea1e0 https://www.ncbi.nlm.nih.gov/pubmed/29628271 https://core.ac.uk/display/158752627 https://cris.maastrichtuniversity.nl/en/publications/functional-network-abnormalities-consistent-with-behavioral-profi https://research.tue.nl/en/publications/functional-network-abnormalities-consistent-with-behavioral-profi |
| Rights: | Elsevier TDM |
| Accession Number: | edsair.doi.dedup.....c13c91de1b11c424fc5a6067182b4f10 |
| Database: | OpenAIRE |
| ISSN: | 09254927 |
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| DOI: | 10.1016/j.pscychresns.2018.02.006 |