Academic Journal
A straightforward procedure to build a non-toxic relaxometry phantom with desired T1 and T2 times at 3T
| Title: | A straightforward procedure to build a non-toxic relaxometry phantom with desired T1 and T2 times at 3T |
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| Authors: | Victor Fritz, Sabine Eisele, Petros Martirosian, Jürgen Machann, Fritz Schick |
| Source: | MAGMA |
| Publisher Information: | Springer Science and Business Media LLC, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Glycine max, Phantoms, Imaging, Glycine max [MeSH], Agar/chemistry [MeSH], T2, Humans [MeSH], Basic Science - Parametric mapping and quantitative MRI, 3T, Kidney/diagnostic imaging [MeSH], Gray Matter/diagnostic imaging [MeSH], Spleen/diagnostic imaging [MeSH], Image Processing, Computer-Assisted/methods [MeSH], Whole Body Imaging/methods [MeSH], MRI Phantom, Reproducibility of Results [MeSH], Gels/chemistry [MeSH], Phantoms, Imaging [MeSH], T1, Soy Lecithin, Relaxometry, Lecithins/chemistry [MeSH], Magnetic Resonance Imaging/methods [MeSH], Imaging, Three-Dimensional/methods [MeSH], Research Article, Liver/diagnostic imaging [MeSH], Reproducibility of Results, Kidney, Magnetic Resonance Imaging, Agar, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Liver, Lecithins, Image Processing, Computer-Assisted, Humans, Whole Body Imaging, Gray Matter, Gels, Spleen |
| Description: | Objective To prepare and analyze soy-lecithin-agar gels for non-toxic relaxometry phantoms with tissue-like relaxation times at 3T. Methods Phantoms mimicking the relaxation times of various tissues (gray and white matter, kidney cortex and medulla, spleen, muscle, liver) were built and tested with a clinical 3T whole-body MR scanner. Simple equations were derived to calculate the appropriate concentrations of soy lecithin and agar in aqueous solutions to achieve the desired relaxation times. Phantoms were tested for correspondence between measurements and calculated T1 and T2 values, reproducibility, spatial homogeneity, and temporal stability. T1 and T2 mapping techniques and a 3D T1-weighted sequence with high spatial resolution were applied. Results Except for the liver relaxation phantom, all phantoms were successfully and reproducibly produced. Good agreement was found between the targeted and measured relaxation times. The percentage deviations from the targeted relaxation times were less than 3% for T1 and less than 6.5% for T2. In addition, the phantoms were homogeneous and had little to no air bubbles. However, the phantoms were unstable over time: after a storage period of 4 weeks, mold growth and also changes in relaxation times were detected in almost all phantoms. Conclusion Soy-lecithin-agar gels are a non-toxic material for the construction of relaxometry phantoms with tissue-like relaxation times. They are easy to prepare, inexpensive and allow independent adjustment of T1 and T2. However, there is still work to be done to improve the long-term stability of the phantoms. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1352-8661 |
| DOI: | 10.1007/s10334-024-01166-7 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/38733487 https://repository.publisso.de/resource/frl:6522679 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....c027db65de8a48f15b12a0e9f0dfb45a |
| Database: | OpenAIRE |
| ISSN: | 13528661 |
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| DOI: | 10.1007/s10334-024-01166-7 |