Academic Journal
Microstructural assessment of the locus coeruleus–entorhinal cortex pathway and association with ATN markers in cognitive impairment
| Title: | Microstructural assessment of the locus coeruleus–entorhinal cortex pathway and association with ATN markers in cognitive impairment |
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| Authors: | Aiello, M., Marizzoni, M., Borrelli, P., Cavaliere, C., Ribaldi, F., Garibotto, V., Scheffler, M., Jelescu, I.O., Jovicich, J., Catani, M., Salvatore, M., Frisoni, G.B., Pievani, M. |
| Source: | Alzheimers Dement Alzheimer's & dementia, vol. 21, no. 4, pp. e70126 |
| Publisher Information: | Wiley, 2025. |
| Publication Year: | 2025 |
| Subject Terms: | Male, Amyloid beta-Peptides, Humans, Locus Coeruleus/diagnostic imaging, Locus Coeruleus/pathology, Locus Coeruleus/metabolism, Female, Cognitive Dysfunction/pathology, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/metabolism, Cross-Sectional Studies, Aged, Entorhinal Cortex/diagnostic imaging, Entorhinal Cortex/pathology, Entorhinal Cortex/metabolism, Biomarkers/metabolism, tau Proteins/metabolism, Positron-Emission Tomography, Magnetic Resonance Imaging, Neural Pathways/pathology, Neural Pathways/diagnostic imaging, Alzheimer Disease/pathology, Alzheimer Disease/diagnostic imaging, Amyloid beta-Peptides/metabolism, Middle Aged, amyloid/tau/neurodegeneration, dementia, diffusion‐weighted imaging, entorhinal cortex, locus coeruleus, magnetic resonance imaging, tau Proteins, Alzheimer Disease, Neural Pathways, Entorhinal Cortex, Locus Coeruleus, Cognitive Dysfunction, Biomarkers, Research Article |
| Description: | INTRODUCTIONWhether Alzheimer's disease pathology involves white matter pathways connecting the locus coeruleus (LC) to the entorhinal cortex (EC) is unclear. In this cross‐sectional observational study, we investigated the microstructural integrity of the LC–EC pathway in relation to amyloid, tau, and neurodegeneration (ATN) biomarkers along the cognitive spectrum from normal cognition to dementia.METHODSOne hundred twenty‐four participants underwent clinical assessment, diffusion‐weighted imaging, structural magnetic resonance imaging (N), amyloid (A), and tau (T) positron emission tomography. Diffusivity indices were assessed in the LC–EC tract using a probabilistic atlas, and linear models were used to assess associations with ATN markers and cognition.RESULTSDifferences in LC–EC microstructural parameters were observed in participants with Braak stage > I versus Braak 0 (p p p p = 0.015).DISCUSSIONOur results suggest that LC–EC diffusivity provides complementary information over ATN biomarkers in explaining cognitive impairment.Highlights Locus coeruleus–entorhinal cortex (LC–EC) tract microstructure is associated with tau and especially neurodegeneration markers. LC–EC tract microstructure is more sensitive to tau pathology and neurodegeneration than tracts commonly affected in Alzheimer's disease. LC–EC diffusivity measures provide complementary information over amyloid, tau, and neurodegeneration (ATN) biomarkers. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1002/alz.70126 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/40289861 https://serval.unil.ch/notice/serval:BIB_4C8321F17AD1 https://serval.unil.ch/resource/serval:BIB_4C8321F17AD1.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4C8321F17AD15 |
| Rights: | CC BY NC |
| Accession Number: | edsair.doi.dedup.....bfc4976b79df67c47dec2713727ad1fd |
| Database: | OpenAIRE |
| ISSN: | 15525279 15525260 |
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| DOI: | 10.1002/alz.70126 |