Academic Journal
Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset
| Τίτλος: | Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset |
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| Συγγραφείς: | Sharkey, RJ, Bacon, C, Peterson, Z, Rootes-Murdy, K, Salvador, R, Pomarol-Clotet, E, Karuk, A, Homan, P, Ji, E, Omlor, W, Homan, S, Georgiadis, F, Kaiser, S, Kirschner, M, Ehrlich, S, Dannlowski, U, Grotegerd, D, Goltermann, J, Meinert, S, Kircher, T, Stein, F, Brosch, K, Krug, A, Nenadic, I, Sim, K, Spalletta, G, Banaj, N, Sponheim, SR, Demro, C, Ramsay, IS, King, M, Quidé, Y, Green, MJ, Nguyen, D, Preda, A, Calhoun, V, Turner, J, van Erp, T, Nickl-Jockschat, T, Quide, Yann |
| Πηγή: | Mol Psychiatry Molecular Psychiatry, vol 29, iss 10 |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2024. |
| Έτος έκδοσης: | 2024 |
| Θεματικοί όροι: | Male, Aging, 5202 Biological Psychology, 32 Biomedical and Clinical Sciences, anzsrc-for: 3214 Pharmacology and Pharmaceutical Sciences, Neurodegenerative, Cohort Studies, Thinking, 0302 clinical medicine, anzsrc-for: 5203 Clinical and health psychology, Alzheimer's Disease Related Dementias (ADRD), Brain, Middle Aged, Serious Mental Illness, Mental Illness, Magnetic Resonance Imaging, 3214 Pharmacology and Pharmaceutical Sciences, Frontotemporal Dementia (FTD), Mental Health, anzsrc-for: 3202 Clinical sciences, 52 Psychology, Neurological, Female, Schizophrenic Psychology, social and economic factors, anzsrc-for: 5202 Biological Psychology, Adult, 1.1 Normal biological development and functioning, Neuroimaging, Basic Behavioral and Social Science, Article, anzsrc-for: 52 Psychology, 03 medical and health sciences, Rare Diseases, anzsrc-for: 32 Biomedical and Clinical Sciences, Clinical Research, 2.3 Psychological, Behavioral and Social Science, Acquired Cognitive Impairment, Humans, anzsrc-for: 17 Psychology and Cognitive Sciences, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Female [MeSH], Brain/pathology [MeSH], 59/57, Adult [MeSH], Humans [MeSH], Middle Aged [MeSH], 692/699/476/1799, Cohort Studies [MeSH], Neuroimaging/methods [MeSH], 38/39, Male [MeSH], Schizophrenic Psychology [MeSH], Thinking/physiology [MeSH], 59, Magnetic Resonance Imaging/methods [MeSH], Schizophrenia/pathology [MeSH], 38, Schizophrenia/physiopathology [MeSH], 631/378, article, anzsrc-for: 11 Medical and Health Sciences, anzsrc-for: 06 Biological Sciences, Schizophrenia, Dementia |
| Περιγραφή: | Formal thought disorder (FTD) is a clinical key factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, the relationship between FTD symptom dimensions and patterns of regional brain volume loss in schizophrenia remains to be established in large cohorts. Even less is known about the cellular basis of FTD. Our study addresses these major obstacles by enrolling a large multi-site cohort acquired by the ENIGMA Schizophrenia Working Group (752 schizophrenia patients and 1256 controls), to unravel the neuroanatomy of FTD in schizophrenia and using virtual histology tools on implicated brain regions to investigate the cellular basis. Based on the findings of previous clinical and neuroimaging studies, we decided to separately explore positive, negative and total formal thought disorder. We used virtual histology tools to relate brain structural changes associated with FTD to cellular distributions in cortical regions. We identified distinct neural networks positive and negative FTD. Both networks encompassed fronto-occipito-amygdalar brain regions, but positive and negative FTD demonstrated a dissociation: negative FTD showed a relative sparing of orbitofrontal cortical thickness, while positive FTD also affected lateral temporal cortices. Virtual histology identified distinct transcriptomic fingerprints associated for both symptom dimensions. Negative FTD was linked to neuronal and astrocyte fingerprints, while positive FTD also showed associations with microglial cell types. These results provide an important step towards linking FTD to brain structural changes and their cellular underpinnings, providing an avenue for a better mechanistic understanding of this syndrome. |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/s41380-024-02563-z |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/38671214 https://repository.publisso.de/resource/frl:6518066 https://escholarship.org/content/qt4093j4b9/qt4093j4b9.pdf https://escholarship.org/uc/item/4093j4b9 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....bcb79946bf443ef42f77e397912b143f |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 14765578 13594184 |
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| DOI: | 10.1038/s41380-024-02563-z |